Kim Shin, Yi Hyon-Ah, Won Kyoung Sook, Lee Ji Soo, Kim Hae Won
Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Korea.
Department of Neurology, Dongsan Hospital, Keimyung University, Daegu 42601, Korea.
Metabolites. 2022 Mar 17;12(3):258. doi: 10.3390/metabo12030258.
The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer's disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (F-FDG) torso positron emission tomography (PET) and F-florbetaben brain PET. F-FDG uptake in VAT on F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A voxel-based analysis revealed that the high VAT metabolism group exhibited a significantly higher cerebral amyloid-β (Aβ) burden than the low VAT metabolism group. In the volume-of-interest analysis, multiple linear regression analyses with adjustment for age, sex, and white matter hyperintensity volume revealed that F-FDG uptake in VAT was significantly associated with the cerebral Aβ burden ( = 0.359, = 0.007). In conclusion, VAT metabolism was associated with AD pathology in older subjects. Our findings suggest that VAT dysfunction could contribute to AD development.
内脏脂肪组织（VAT）已被公认为一种内分泌器官，VAT功能障碍可能是阿尔茨海默病（AD）的一个风险因素。我们旨在评估VAT代谢与AD病理学之间的关联。这项横断面研究纳入了54名有认知障碍的老年受试者，他们接受了2-脱氧-2-[氟-18]-氟-D-葡萄糖（F-FDG）躯干正电子发射断层扫描（PET）和F-氟贝他班脑PET检查。F-FDG PET图像上VAT的F-FDG摄取被用作VAT代谢的标志物，受试者被分为高VAT代谢组和低VAT代谢组。基于体素的分析显示，高VAT代谢组的脑淀粉样β蛋白（Aβ）负荷显著高于低VAT代谢组。在感兴趣区分析中，对年龄、性别和白质高信号体积进行校正的多元线性回归分析显示，VAT的F-FDG摄取与脑Aβ负荷显著相关（ = 0.359， = 0.007）。总之，在老年受试者中，VAT代谢与AD病理学相关。我们的研究结果表明，VAT功能障碍可能促成AD的发展。
