Division of General Internal Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI.
Diabetes Care. 2020 Apr;43(4):759-766. doi: 10.2337/dc19-1586. Epub 2020 Feb 6.
This study aimed to understand the longitudinal relationship between financial, psychosocial, and neighborhood social determinants and glycemic control (HbA) in older adults with diabetes.
Data from 2,662 individuals with self-reported diabetes who participated in the Health and Retirement Study (HRS) were used. Participants were followed from 2006 through 2014. Financial hardship, psychosocial, and neighborhood-level social determinant factors were based on validated surveys from the biennial core interview and RAND data sets. All social determinant factors and measurements of HbA from the time period were used and treated as time varying in analyses. SAS PROC GLIMMIX was used to fit a series of hierarchical linear mixed models. Models controlled for nonindependence among the repeated observations using a random intercept and treating each individual participant as a random factor. Survey methods were used to apply HRS weighting.
Before adjustment for demographics, difficulty paying bills (β = 0.18 [95% CI 0.02, 0.24]) and medication cost nonadherence (0.15 [0.01, 0.29]) were independently associated with increasing HbA over time, and social cohesion (-0.05 [-0.10, -0.001]) was independently associated with decreasing HbA over time. After adjusting for both demographics and comorbidity count, difficulty paying bills (0.13 [0.03, 0.24]) and religiosity (0.04 [0.001, 0.08]) were independently associated with increasing HbA over time.
Using a longitudinal cohort of older adults with diabetes, this study found that financial hardship factors, such as difficulty paying bills, were more consistently associated with worsening glycemic control over time than psychosocial and neighborhood factors.
本研究旨在了解财务、心理社会和邻里社会决定因素与老年糖尿病患者血糖控制(HbA)之间的纵向关系。
本研究使用了参加健康与退休研究(HRS)的 2662 名自我报告患有糖尿病的个体的数据。参与者从 2006 年随访至 2014 年。财务困难、心理社会和邻里层面的社会决定因素是基于两年一次的核心访谈和 RAND 数据集的验证调查。在分析中,使用了所有社会决定因素和 HbA 的测量值,并将其视为随时间变化的变量。SAS PROC GLIMMIX 用于拟合一系列层次线性混合模型。模型通过随机截距控制非独立性,并将每个个体参与者视为随机因素。使用调查方法应用 HRS 权重。
在调整人口统计学因素之前,难以支付账单(β=0.18[95%CI 0.02,0.24])和药物费用不依从(0.15[0.01,0.29])与 HbA 随时间增加独立相关,而社会凝聚力(-0.05[-0.10,-0.001])与 HbA 随时间降低独立相关。在调整人口统计学因素和合并症计数后,难以支付账单(0.13[0.03,0.24])和宗教信仰(0.04[0.001,0.08])与 HbA 随时间增加独立相关。
本研究使用老年糖尿病患者的纵向队列发现,与心理社会和邻里因素相比,财务困难因素(如难以支付账单)与血糖控制恶化的相关性在时间上更为一致。