Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Curr Neuropharmacol. 2020;18(10):918-935. doi: 10.2174/1570159X18666200207120949.
A transcriptional regulatory nuclear factor kappa B (NF-κB) protein is a modulator of cellular biological activity via binding to a promoter region in the nucleus and transcribing various protein genes. The recent research implicated the intensive role of nuclear factor kappa B (NF-κB) in diseases like autoimmune disorder, inflammatory, cardiovascular and neurodegenerative diseases. Therefore, targeting the nuclear factor kappa B (NF-κB) protein offers a new opportunity as a therapeutic approach. Activation of IκB kinase/NF-κB signaling pathway leads to the development of various pathological conditions in human beings, such as neurodegenerative, inflammatory disorders, autoimmune diseases, and cancer. Therefore, the transcriptional activity of IκB kinase/NF- κB is strongly regulated at various cascade pathways. The nuclear factor NF-kB pathway plays a major role in the expression of pro-inflammatory genes, including cytokines, chemokines, and adhesion molecules. In response to the diverse stimuli, the cytosolic sequestered NF-κB in an inactivated form by binding with an inhibitor molecule protein (IkB) gets phosphorylated and translocated into the nucleus further transcribing various genes necessary for modifying various cellular functions. The various researches confirmed the role of different family member proteins of NF-κB implicated in expressing various genes products and mediating various cellular cascades. MicroRNAs, as regulators of NF- κB microRNAs play important roles in the regulation of the inflammatory process. Therefore, the inhibitor of NF-κB and its family members plays a novel therapeutic target in preventing various diseases. Regulation of NF- κB signaling pathway may be a safe and effective treatment strategy for various disorders.
转录调节核因子 kappa B（NF-κB）蛋白是一种通过与核内启动子区域结合并转录各种蛋白基因来调节细胞生物活性的调节剂。最近的研究表明，核因子 kappa B（NF-κB）在自身免疫性疾病、炎症、心血管和神经退行性疾病等疾病中起着重要作用。因此，针对核因子 kappa B（NF-κB）蛋白提供了一种新的治疗方法的机会。IκB 激酶/NF-κB 信号通路的激活导致人类各种病理状况的发展，如神经退行性疾病、炎症性疾病、自身免疫性疾病和癌症。因此，IκB 激酶/NF-κB 的转录活性在各种级联途径中受到强烈调节。核因子 NF-kB 途径在促炎基因的表达中起主要作用，包括细胞因子、趋化因子和粘附分子。为了应对各种刺激，细胞溶质中与抑制剂分子蛋白（IkB）结合的 NF-κB 以失活形式被隔离，并被磷酸化并易位到核内，进一步转录各种必需的基因，以修饰各种细胞功能。各种研究证实了 NF-κB 不同家族成员蛋白在表达各种基因产物和介导各种细胞级联中所起的作用。miRNA 作为 NF-κB 的调节剂，miRNA 在炎症过程的调节中起着重要作用。因此，NF-κB 及其家族成员的抑制剂在预防各种疾病中发挥着新的治疗靶点作用。NF-κB 信号通路的调节可能是预防各种疾病的一种安全有效的治疗策略。
