Belch J J, Land D, Park R H, McKillop J H, MacKenzie J F
University Department of Medicine, Ninewells Hospital, Dundee.
Br J Rheumatol. 1988 Dec;27(6):426-30. doi: 10.1093/rheumatology/27.6.426.
Cold-induced vasospasm seen in systemic sclerosis (SS) and Raynaud's phenomenon (RP) has previously been thought to be limited to peripheral skin sites. However, the oesophageal problems seen in SS cannot be sufficiently explained by connective tissue damage/abnormal motility alone. We wondered if temperature dependent ischaemia could occur in the oesophageal microcirculation. We have measured oesophageal temperature variation following oesophageal cold challenge: 50 ml of water at 7 degrees C and 17 degrees C, with 37 degrees C used as control, were introduced into the mid-oesophagus at a rate of 2 ml/s. Temperature was recorded using a thermocouple probe 5 cm above the gastro-oesophageal junction. The test was performed on 14 SS patients, eight patients with Raynaud's disease and 21 controls. The control's rewarming pattern followed a simple exponential curve. This did not vary with temperature or after repeated challenge. In the SS patients the time constant was significantly longer after cold challenge.
系统性硬化症（SS）和雷诺现象（RP）中出现的冷诱导血管痉挛以前被认为仅限于外周皮肤部位。然而，仅靠结缔组织损伤/异常蠕动无法充分解释SS中出现的食管问题。我们想知道食管微循环中是否会发生温度依赖性缺血。我们测量了食管冷刺激后的食管温度变化：将50毫升7摄氏度和17摄氏度的水，以2毫升/秒的速度注入食管中部，以37摄氏度作为对照。使用位于胃食管交界处上方5厘米处的热电偶探头记录温度。对14例SS患者、8例雷诺病患者和21例对照进行了测试。对照组的复温模式遵循简单的指数曲线。这不会随温度变化或在重复刺激后改变。在SS患者中，冷刺激后的时间常数明显更长。
