Iran Polymer and Petrochemical Institute, PO Box: 14965/115, Tehran, Iran.
Biomed Mater. 2020 May 5;15(4):045001. doi: 10.1088/1748-605X/ab7387.
Preparation of efficient polyurethane-type wound dressings with tunable physicomechanical properties and widespread antimicrobial activity is considered in this work. A new type of soybean oil-based polyol with built-in urethane and quaternary ammonium groups is synthesized through a nonisocyanate route using carbonated soybean oil as an environmentally friendly, renewable resource-based raw material. Different formulations from this polyol and castor oil are prepared and converted to the polyurethane wound dressings via a reaction with isophorone diisocyanate. The dressing sample, with good cytocompatibility and efficient antimicrobial activity against various microbial strains, having tensile strength of 5 and 17 MPa at hydrated and dry state, elongation at the break of up to 400%, equilibrium water absorption and a water vapor transmission rate of 50% and 390 g m day, is used for in vivo assay on a rat. Evaluation of the optimized dressing for a full-thickness non-sterilized wound has shown excellent progress of wound healing, since the tensile strength of regenerated skin reaches about 80% of normal healthy skin on day 21 after wounding. This has been significantly superior to the tensile strength of the regenerated skin of rats covered with non-antibacterial (∼50%) and cotton gauze (∼40%) dressings as blank and control groups.
这项工作旨在制备具有可调物理机械性能和广泛抗菌活性的高效聚氨酯型伤口敷料。通过非异氰酸酯路线，使用碳酸化大豆油作为环保、可再生资源的原料，合成了一种新型的内置聚氨酯和季铵基团的大豆油基多元醇。使用这种多元醇和蓖麻油的不同配方，并通过与异佛尔酮二异氰酸酯反应，将其转化为聚氨酯伤口敷料。这种敷料样品具有良好的细胞相容性和对各种微生物菌株的高效抗菌活性，在水合和干燥状态下的拉伸强度分别为 5 和 17 MPa，断裂伸长率高达 400%，平衡吸水率和水蒸气透过率分别为 50%和 390 g m-2 day-1，用于大鼠体内试验。对未经消毒的全层伤口的优化敷料进行评估表明，伤口愈合进展良好，因为受伤后第 21 天再生皮肤的拉伸强度达到正常健康皮肤的约 80%。这明显优于未抗菌（约 50%）和棉纱布（约 40%）敷料覆盖的大鼠再生皮肤的拉伸强度，作为空白和对照组。
