Pinelli Filippo, Perale Giuseppe, Rossi Filippo
Dipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, via Mancinelli 7, 20131 Milan, Italy.
Faculty of Biomedical Sciences, University of Southern Switzerland (USI), Via Buffi 13, 6900 Lugano, Switzerland.
Gels. 2020 Feb 4;6(1):6. doi: 10.3390/gels6010006.
Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be adopted in order to modify the selectivity of the nanoparticles in the delivery process and obtain a final system with great targeted drug delivery ability. We also highlight the most important fields of application of these kinds of delivery systems and we propose a comparison between the advantages and disadvantages of the described functionalization strategies.
药物递送是一个极具吸引力的研究领域，有多个发展机遇。目前，人们高度关注胶体系统、纳米颗粒和纳米凝胶，以及对它们进行改性以获得精确靶向药物递送系统的可能性。本综述的目的是概述主要可用的表面功能化和包衣策略，这些策略可用于在递送过程中改变纳米颗粒的选择性，从而获得具有强大靶向药物递送能力的最终系统。我们还强调了这类递送系统最重要的应用领域，并对所描述的功能化策略的优缺点进行了比较。
