Kridin Khalaf, Jones Virginia A, Patel Payal M, Gibson Frederick T, Amber Kyle T, Cohen Arnon D
Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.
Department of Dermatology, University of Illinois At Chicago, 808 S Wood St, RM377, Chicago, IL, 60612, USA.
Arch Dermatol Res. 2020 Sep;312(7):501-505. doi: 10.1007/s00403-020-02040-x. Epub 2020 Feb 7.
A recent study of comorbidities in hospitalized pemphigus patients in the United States has demonstrated a significant association of hidradenitis suppurativa (HS) and pemphigus, but this association has not been firmly established in other populations. A retrospective, cross-sectional study was undertaken to determine the prevalence of HS in patients with pemphigus and compare with control subjects. Regression analysis was performed to obtain ORs, and 95% CIs, to evaluate the prevalence between pemphigus patients and controls matched by age, sex, and ethnicity. Among the patients included in the study, 1985 patients had pemphigus and 9874 were control subjects. The average age of presentation of pemphigus was 72.1 ± 18.5 and the group was comprised of 59.8% females. Overall, the pemphigus group had lower rates of smoking (25.7% vs. 27.9%; P = 0.045). The prevalence of HS was greater in patients with pemphigus than in control subjects (OR 4.98; 95% CI 1.01-24.69; P < 0.001), with an even more prominent association among patients who have been prescribed "pemphigus-related treatments" (OR 6.30; 95% CI 1.27-31.22; P < 0.001). The study detected a significant association between HS and pemphigus in an Israeli population. Future prospective studies are needed to establish a temporal order of appearance and the mechanistic relationship between these entities.
美国一项关于住院天疱疮患者合并症的近期研究表明，化脓性汗腺炎（HS）与天疱疮之间存在显著关联，但这种关联在其他人群中尚未得到确凿证实。本研究进行了一项回顾性横断面研究，以确定天疱疮患者中HS的患病率，并与对照组进行比较。进行回归分析以获得比值比（OR）和95%置信区间（CI），以评估年龄、性别和种族相匹配的天疱疮患者与对照组之间的患病率。在纳入研究的患者中，1985例患有天疱疮，9874例为对照对象。天疱疮患者的平均发病年龄为72.1±18.5岁，该组女性占59.8%。总体而言，天疱疮组的吸烟率较低（25.7%对27.9%；P = 0.045）。天疱疮患者中HS的患病率高于对照组（OR 4.98；95% CI 1.01 - 24.69；P < 0.001），在接受“天疱疮相关治疗”的患者中这种关联更为显著（OR 6.30；95% CI 1.27 - 31.22；P < 0.001）。该研究在以色列人群中检测到HS与天疱疮之间存在显著关联。未来需要进行前瞻性研究，以确定这些疾病出现的时间顺序及其机制关系。
