Lűbeck Institute of Experimental Dermatology, University of Lűbeck, RatzeburgerAllee 160, 23562, Lübeck, Germany.
Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA.
Arch Dermatol Res. 2021 Jul;313(5):333-337. doi: 10.1007/s00403-020-02105-x. Epub 2020 Jul 16.
The association between acne keloidalis nuchae (AKN) and hidradenitis suppurativa (HS) is yet to be investigated. To determine the link between AKN and HS using a large computerized health maintenance database. A cross-sectional study design was used to assess the prevalence of HS in patients with AKN and in control participants matched by age, sex, and ethnicity. A total of 2677 participants with AKN and 13,190 control participants were studied. An increased prevalence of HS was observed in the AKN group compared to the control group (1.0% vs. 0.3%, respectively; OR, 3.6; 95% CI 2.2-5.8; P < 0.001), especially among those younger than 20 years (OR, 10.2; 95% CI 3.1-34.2; P < 0.001), and females (OR, 15.7; 95% CI 3.1-78.8; P < 0.001). After adjusting for confounding factors, the multivariate analysis demonstrated a persistent association of AKN with HS (adjusted OR, 3.6; 95% CI 2.1-5.9; P < 0.001). This study demonstrated a significant association between AKN and HS in an Israeli population. The threshold for diagnosis of HS among patients with AKN must be lowered in patients presenting with concerning symptoms. Further observational studies in other patient populations will help confirm this relationship.
尚未研究痤疮性瘢痕性脱发（AKN）和化脓性汗腺炎（HS）之间的关联。使用大型计算机健康维护数据库确定 AKN 和 HS 之间的联系。采用横断面研究设计评估 AKN 患者中 HS 的患病率，并在年龄、性别和种族匹配的对照组参与者中进行评估。共研究了 2677 名 AKN 患者和 13190 名对照组参与者。与对照组相比，AKN 组 HS 的患病率更高（分别为 1.0%和 0.3%；OR，3.6；95%CI 2.2-5.8；P<0.001），尤其是 20 岁以下的患者（OR，10.2；95%CI 3.1-34.2；P<0.001）和女性（OR，15.7；95%CI 3.1-78.8；P<0.001）。在调整混杂因素后，多变量分析显示 AKN 与 HS 持续相关（调整 OR，3.6；95%CI 2.1-5.9；P<0.001）。本研究在以色列人群中证实了 AKN 和 HS 之间存在显著关联。对于出现相关症状的 AKN 患者，HS 的诊断阈值必须降低。在其他患者群体中进行进一步的观察性研究将有助于证实这种关系。
