Benson E A, Benson J W, Fredlund P N, Mecklenburg R S, Metz R
Virginia Mason Clinic, Section of Endocrinology and Diabetes, Seattle, WA 98111.
Diabetes Care. 1988 Jul-Aug;11(7):563-6. doi: 10.2337/diacare.11.7.563.
In late 1986, several vials of Humulin N (NPH human insulin, recombinant DNA origin) came to our attention because of a clumped, white coating on the inside of the vials. To determine the frequency of this phenomenon, we surveyed 100 consecutive patients who used Humulin N. Ten patients had encountered 21 vials of flocculated insulin in the previous 12 mo, reflecting an incidence of 1 per 72 vials. Insulin drawn from affected vials was markedly reduced in potency: 20.9 +/- 3.4 U/ml vs. the labeled potency of 100 U/ml. Several patients reporting flocculated insulin, including one hospitalized with ketoacidosis, experienced unusual and unexplained elevation in blood glucose concentration for several days before flocculation was observed. Patients who use NPH human insulin should be aware of this phenomenon and carefully inspect their vials for evidence of insulin precipitation before each injection.
1986年末，几瓶优泌林N（NPH人胰岛素，重组DNA来源）引起了我们的注意，因为瓶内出现了结块的白色涂层。为确定这种现象的发生频率，我们对连续100例使用优泌林N的患者进行了调查。10名患者在过去12个月内遇到了21瓶出现絮凝的胰岛素，发生率为每72瓶中有1瓶。从受影响的瓶中抽取的胰岛素效价明显降低：为20.9±3.4 U/ml，而标签上的效价为100 U/ml。几名报告胰岛素出现絮凝的患者，包括一名因酮症酸中毒住院的患者，在观察到絮凝前几天血糖浓度出现了异常且无法解释的升高。使用NPH人胰岛素的患者应注意这种现象，并在每次注射前仔细检查药瓶是否有胰岛素沉淀的迹象。
