College of Food Science and Engineering, Zhejiang University of Technology, 310014 Hangzhou, PR China.
Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Int J Biol Macromol. 2020 May 1;150:765-774. doi: 10.1016/j.ijbiomac.2020.02.035. Epub 2020 Feb 6.
Ganoderma lucidum, commonly known as "Lingzhi" in Chinese, are well-known medicinal mushrooms. Lingzhi has been used in traditional Chinese herbal medicines for more than two thousand years. G. lucidum polysaccharides (GLPs) are present at high levels in G. lucidum cells and GLPs have molecular weights ranging from thousands to millions. GLPs have been widely studied for their various biological activities, such as antioxidant, antitumor, anti-inflammatory, antiviral, anti-diabetes, and immunomodulatory activities. The methods for GLPs extraction and characterization are mature, but the comprehensive research on the relationship between GLPs structure (i.e., molecular weight, tertiary structure, branching, substituents, and monosaccharide composition) and function is still quite limited. The aim of this review is to update and summarize the mechanisms of the various bioactive polysaccharides extracted from G. lucidum. The information presented on these bio-mechanisms should be valuable in the research and development of GLPs-derived therapeutics.
灵芝，俗称“灵芝”，是一种著名的药用蘑菇。灵芝在中国传统草药中已经使用了两千多年。灵芝多糖（GLPs）在灵芝细胞中含量很高，GLPs 的分子量范围从几千到几百万不等。GLPs 因其各种生物活性而被广泛研究，如抗氧化、抗肿瘤、抗炎、抗病毒、抗糖尿病和免疫调节活性。GLPs 的提取和表征方法已经成熟，但 GLPs 结构（即分子量、三级结构、分支、取代基和单糖组成）与功能之间关系的综合研究仍然相当有限。本综述的目的是更新和总结从灵芝中提取的各种生物活性多糖的作用机制。这些生物机制的信息对于 GLPs 衍生疗法的研究和开发应该是有价值的。
