膜钠转运对普通男性人群血铅与血压关系的影响。
Influence of membrane sodium transport upon the relation between blood lead and blood pressure in a general male population.
作者信息
Moreau T, Hannaert P, Orssaud G, Huel G, Garay R P, Claude J R, Juguet B, Festy B, Lellouch J
机构信息
INSERM, Unité 169, Villejuif, France.
出版信息
Environ Health Perspect. 1988 Jun;78:47-51. doi: 10.1289/ehp.887847.
Five red blood cell cation transport systems (RBCTS), together with blood lead level and blood pressure, were measured in 129 male adult subjects who were not occupationally exposed to lead or subsequent to a course of treatment for hypertension. Blood lead was positively related with systolic blood pressure, and to a lesser degree with diastolic blood pressure. Blood lead was found significantly negatively related to one of the RBCTS, Na+,K+ cotransport, and in addition, Na+,K+ cotransport appeared negatively related to blood pressure. Final results showed that blood lead no longer accounts for an increase in systolic blood pressure when Na+,K+ cotransport was taken into account; the same trend was observed with diastolic blood pressure. These findings suggest that a blood lead-related Na+,K+ cotransport impairment could explain the blood pressure increase observed to parallel the blood lead increase.
在129名未职业性接触铅或经过高血压治疗疗程后的成年男性受试者中，测量了五种红细胞阳离子转运系统（RBCTS）以及血铅水平和血压。血铅与收缩压呈正相关，与舒张压的相关性较小。发现血铅与RBCTS之一的钠钾协同转运显著负相关，此外，钠钾协同转运与血压呈负相关。最终结果表明，当考虑钠钾协同转运时，血铅不再是收缩压升高的原因；舒张压也观察到相同趋势。这些发现表明，与血铅相关的钠钾协同转运受损可能解释了与血铅升高平行出现的血压升高现象。
Zotero 插件