Chartier C, Ravinet N, Bosco A, Dufourd E, Gadanho M, Chauvin A, Charlier J, Maurelli M P, Cringoli G, Rinaldi L
INRAE, Oniris, BIOEPAR, 44300Nantes, France.
Department of Veterinary Medicine and Animal Production, University of Napoli Federico II, CREMOPAR, Napoli, Italy.
J Helminthol. 2020 Feb 10;94:e125. doi: 10.1017/S0022149X20000085.
Our objective was to measure the efficacy of ivermectin (IVM) and benzimidazoles (BZ, i.e. fenbendazole and albendazole) in 15 cattle farms in western France and southern Italy. A total of 11 groups were treated with IVM and 11 with BZ. Efficacy was assessed by calculating the percentage of faecal egg count reduction (%FECR) using the pre- and post-treatment arithmetic means. Anthelmintic resistance was considered to be present when the %FECR was <95% and the lower limit of the 95% confidence interval <90%. For IVM, the percentages of FECR ranged from 73% to 100%. Lack of efficacy to IVM was detected in two farms out of four in France, but was not detected in any of the seven farms in Italy. For BZ, the percentages of FECR ranged from 95% to 100%. No case of BZ resistance was detected in the five farms in France and the six farms in Italy.
我们的目标是在法国西部和意大利南部的15个养牛场中测定伊维菌素（IVM）和苯并咪唑类药物（BZ，即芬苯达唑和阿苯达唑）的疗效。共有11组接受IVM治疗，11组接受BZ治疗。通过使用治疗前和治疗后的算术平均值计算粪便虫卵计数减少百分比（%FECR）来评估疗效。当%FECR<95%且95%置信区间的下限<90%时，则认为存在抗蠕虫药耐药性。对于IVM，FECR百分比范围为73%至100%。在法国的4个农场中有2个检测到对IVM无效，但在意大利的7个农场中均未检测到。对于BZ，FECR百分比范围为95%至100%。在法国的5个农场和意大利的6个农场中均未检测到BZ耐药情况。
