Ghajarzadeh Mahsa, Jalilian Rozita, Sahraian Mohammad Ali, Moghadasi Abdorreza Naser, Azimi Amirreza, Mohammadifar Mehdi, Azizi Sepehr
Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Tehran University of Medical Sciences, Tehran, Iran.
Maedica (Bucur). 2018 Jun;13(2):125-130. doi: 10.26574/maedica.2018.13.2.125.
Multiple sclerosis is a chronic inflammatory disease which affects the central nervous system. Many patients with multiple sclerosis suffer from persistent pain during the disease course. In Iranian cases, pain has not been regarded as it should be.
The goal of this study was to determine the prevalence and types of pain in Iranian multiple sclerosis patients.
This cross sectional study was conducted in the multiple sclerosis clinic of Sina Hospital between October 2014 and August 2015. Eighty eight multiple sclerosis patients were enrolled. Participants were asked to fill a valid and reliable Persian version of the Brief Pain Inventory. Demographic data (sex, age), disease duration and disease course were extracted from patients' medical files. All patients were examined by an expert neurologist to obtain Kurtzke Expanded Disability Status Scale (EDSS).
The mean age and mean duration of disease were 30.4±7.6 years and 5.9±4 years, respectively. Median EDSS was 1. All patients reported pain. The most common sites of pain were upper extremities (52.3%). Higher the EDSS score, higher pain interference with the evaluated items. By using the worst pain intensity as a dependent variable, and age, sex, EDSS, disease duration and type of disease as independent variables, regression analysis showed that the EDSS score was an independent predictor for the intensity of pain in this group of patients.
Pain is a common symptom found in patients diagnosed with multiple sclerosis. Thus, an accurate and thorough assessment of pain should be integrated in the routine evaluation of patients diagnosed with multiple sclerosis.
多发性硬化症是一种影响中枢神经系统的慢性炎症性疾病。许多多发性硬化症患者在病程中遭受持续性疼痛。在伊朗的病例中，疼痛并未得到应有的重视。
本研究的目的是确定伊朗多发性硬化症患者疼痛的患病率和类型。
本横断面研究于2014年10月至2015年8月在西娜医院的多发性硬化症诊所进行。招募了88名多发性硬化症患者。参与者被要求填写一份有效且可靠的波斯语版简明疼痛问卷。从患者的病历中提取人口统计学数据（性别、年龄）、疾病持续时间和病程。所有患者均由一名神经科专家进行检查以获得库尔特克扩展残疾状态量表（EDSS）。
平均年龄和平均病程分别为30.4±7.6岁和5.9±4年。EDSS中位数为1。所有患者均报告有疼痛。最常见的疼痛部位是上肢（52.3%）。EDSS评分越高，疼痛对所评估项目的干扰越大。以最严重疼痛强度作为因变量，年龄、性别、EDSS、疾病持续时间和疾病类型作为自变量，回归分析表明EDSS评分是该组患者疼痛强度的独立预测因素。
疼痛是多发性硬化症患者中常见的症状。因此，在对多发性硬化症患者的常规评估中应纳入对疼痛的准确和全面评估。
