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异质氧化石墨烯作为可循环催化剂用于甲亚胺叶立德介导的水相中1,3-偶极环加成反应。

Heterogeneous graphene oxide as recyclable catalyst for azomethine ylide mediated 1,3 dipolar cycloaddition reaction in aqueous medium.

作者信息

Reddy Marri Sameer, Kumar Nandigama Satish, Chowhan L Raju

机构信息

School of Chemical Sciences, Central University of Gujarat Sector 30 Gandhinagar-382030 India.

Nanoscience and Nanotechnology Laboratory, Department of Chemistry, Gitam Institute of Sciences, Gitam University Visakhapatnam 530045 India.

出版信息

RSC Adv. 2018 Oct 17;8(62):35587-35593. doi: 10.1039/c8ra06714g. eCollection 2018 Oct 15.

DOI:10.1039/c8ra06714g
PMID:35547897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9088037/
Abstract

Graphene oxide (GO) catalysed multi component reaction of azomethine ylide driven 1,3 dipolar cycloaddition reaction in aqueous ethanolic solution is reported for the first time. This strategy has been applied for the synthesis of poly heterocyclic spiro-indenoquinoxaline pyrrolizidines and spiro-oxindoles pyrrolizidines with good to excellent yield along with excellent regio and diastereoselectivity. An ultra-low catalyst loading of 0.50 wt% was found to be efficient to catalyse the reaction.

摘要

首次报道了氧化石墨烯（GO）在乙醇水溶液中催化偶氮甲碱叶立德驱动的1,3-偶极环加成多组分反应。该策略已应用于合成多杂环螺茚并喹喔啉吡咯里西啶和螺氧化吲哚吡咯里西啶，产率良好至优异，同时具有优异的区域和非对映选择性。发现0.50 wt%的超低催化剂负载量能有效催化该反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/c19f78bb9f52/c8ra06714g-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/f4bd9fc9bceb/c8ra06714g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/bf0a8bb527c0/c8ra06714g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/9bcc93f41f2f/c8ra06714g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/febc04c5955b/c8ra06714g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/25900aef2a4d/c8ra06714g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/b097821ed3b1/c8ra06714g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/68447e377493/c8ra06714g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/9caa1940f42e/c8ra06714g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/c19f78bb9f52/c8ra06714g-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/f4bd9fc9bceb/c8ra06714g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/bf0a8bb527c0/c8ra06714g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/9bcc93f41f2f/c8ra06714g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/febc04c5955b/c8ra06714g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/25900aef2a4d/c8ra06714g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/b097821ed3b1/c8ra06714g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/68447e377493/c8ra06714g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/9caa1940f42e/c8ra06714g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ea4/9088037/c19f78bb9f52/c8ra06714g-f7.jpg

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