Yong-Quan Ng Gavin, Fann David Yang-Wei, Jo Dong-Gyu, Sobey Christopher G, Arumugam Thiruma V
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Cond Med. 2019 Dec;2(6):300-310.
In the first part of our review, we extensively discuss the different variants of dietary restriction (DR) regimens, as well as its corresponding mechanism(s) and subsequent effects. We also provide a detailed analysis of the different epigenetic mechanisms based on current knowledge. We postulate that DR may represent an environmental intervention that can modulate the epigenomic profile of an individual. It is highly plausible that epigenetic regulation by DR may help explain the asymmetric manifestation of DR effects in different individuals. Additionally, epigenetic modifications via DR may lead to epigenetic programming, providing protection against age-associated diseases, which in turn could lead to reduced morbidity and increased lifespan. In the second part of the review, we summarize recent findings that highlight the epigenomic axis of DR, which provides a better understanding of the mechanisms by which its numerous health benefits are achieved.
在我们综述的第一部分，我们广泛讨论了饮食限制（DR）方案的不同变体，以及其相应的机制和后续影响。我们还根据现有知识对不同的表观遗传机制进行了详细分析。我们推测，饮食限制可能代表一种环境干预，能够调节个体的表观基因组特征。饮食限制的表观遗传调控很可能有助于解释其在不同个体中效应的不对称表现。此外，通过饮食限制进行的表观遗传修饰可能导致表观遗传编程，提供针对与年龄相关疾病的保护，这反过来可能导致发病率降低和寿命延长。在综述的第二部分，我们总结了近期的研究发现，这些发现突出了饮食限制的表观基因组轴，从而能更好地理解实现其众多健康益处的机制。
