五倍子醌，一种来自黄色海绵 cf. 埃斯佩的 Merosesquiterpene。

Quintaquinone, a Merosesquiterpene from the Yellow Sponge cf. Esper.

机构信息

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences , Prince of Songkla University , Hat-Yai , Songkhla 90112 , Thailand.

Division of Pharmaceutical Sciences, Faculty of Pharmacy , Thammasat University , Klong Luang , Pathumthani 12120 , Thailand.

出版信息

J Nat Prod. 2020 Feb 28;83(2):532-536. doi: 10.1021/acs.jnatprod.9b00886. Epub 2020 Feb 10.

DOI:10.1021/acs.jnatprod.9b00886

PMID:32040314

Abstract

A chemical investigation of the sponge cf. led to the isolation of 13 merosesquiterpenes, among which quintaquinone (), 5--nakijiquinone L (), and 3-farnesyl-2-hydroxy-5-methoxyquinone () were isolated and reported here for the first time. Particularly, compound is the first member of merosesquiterpenes with a polyketide side chain substituted on C-19. All of the isolated compounds were examined for steroid 5α-reductase inhibitory activity. Cyclospongiaquinone 1 () showed a strong activity in the same range as that of standard finasteride.

摘要

对 cf. 海绵的化学研究导致了 13 种倍半萜的分离，其中 quinquenaquinone ()、5--nakijiquinone L ()和 3-香叶基-2-羟基-5-甲氧基醌 ()被分离出来，并首次在这里报道。特别是，化合物是具有在 C-19 上取代的聚酮侧链的倍半萜类的第一个成员。所有分离出的化合物都被检测了对甾体 5α-还原酶的抑制活性。海绵甾酮 1 ()显示出与标准非那雄胺相当的强烈活性。