来自澳大利亚海绵指状希氏海绵的倍半萜类同系物作为动脉粥样硬化疾病的潜在药物先导物

Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease.

作者信息

Wahab Huda A, Pham Ngoc B, Muhammad Tengku S Tengku, Hooper John N A, Quinn Ronald J

机构信息

Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia.

School of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia.

出版信息

Mar Drugs. 2016 Dec 27;15(1):6. doi: 10.3390/md15010006.

A study of the chemical constituents from the Australian Sponge has provided a perspective on the connection between the chemistry and biology of the puupehenones, a unique and unusual class of merosesquiterpenes. In this study, a new tetracyclic merosesquiterpene, 19-methoxy-9,15-ene-puupehenol () was isolated from the marine sponge along with the known 20-methoxy-9,15-ene-puupehenol (). Their structures were elucidated on the basis of spectroscopic data (¹H and C NMR) in combination with experimental electronic circular dichroism (ECD) data. Compounds and are active at 1.78 μM and 3.05 μM, respectively, on Scavenger Receptor-Class B Type 1 HepG2 (SR-B1 HepG2) stable cell lines, targeting atherosclerosis disease.