聚（ADP-核糖）聚合酶与ADP-核糖基化：60年回顾
PARPs and ADP-ribosylation: 60 years on.
作者信息
Kraus W Lee
机构信息
Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
出版信息
Genes Dev. 2020 Feb 6;34(5-6):251-3. doi: 10.1101/gad.336420.120.
Abstract
Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of includes seven reviews that highlight these discoveries and point the way forward for future advances in the field.
摘要
对聚（ADP-核糖）聚合酶（PARPs）的研究取得了重大进展并达到了重要里程碑。PARPs是一类催化ADP核糖基化（蛋白质的一种翻译后修饰）的酶。在过去十年中，除了以往对DNA修复的关注领域之外，还出现了许多新发现，这些发现正在影响对人类疾病的理解和治疗。本期特刊的这个专题部分包含七篇综述，突出了这些发现，并为该领域未来的进展指明了方向。
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2
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Genes Dev. 2020 Mar 1;34(5-6):321-340. doi: 10.1101/gad.334284.119. Epub 2020 Feb 6.
3
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Genes Dev. 2020 Mar 1;34(5-6):360-394. doi: 10.1101/gad.334516.119. Epub 2020 Feb 6.
4
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8
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Science. 2016 Jul 1;353(6294):45-50. doi: 10.1126/science.aaf7865. Epub 2016 Jun 2.
10
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