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具有各向异性表面附着力的仿生结构色补丁。

Bioinspired structural color patch with anisotropic surface adhesion.

机构信息

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

出版信息

Sci Adv. 2020 Jan 24;6(4):eaax8258. doi: 10.1126/sciadv.aax8258. eCollection 2020 Jan.

DOI:10.1126/sciadv.aax8258
PMID:32042897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6981080/
Abstract

Patch plays an important role in clinical medicine for its broad applications in tissue repair and regeneration. Here, inspired by the diverse adhesion, anti-adhesion, and responsive structural color phenomena in biological interfaces, we present a hybrid hydrogel film with an adhesive polydopamine (PDA) layer and an anti-adhesive poly(ethylene glycol) diacrylate (PEGDA) layer in an inverse opal scaffold. It was demonstrated that the resultant hydrogel film could serve as a functional tissue patch with an excellent adhesion property on one surface for repairing injured tissues and an anti-adhesion property on the other surface for preventing adverse adhesion. Besides, because of the responsive structural color, the patch was imparted with self-reporting mechanical capability, which could provide a real-time color-sensing feedback to monitor the heartbeat activity. Moreover, the catechol groups on PDA imparted the patch with high tissue adhesiveness and self-healing capability in vivo. These features give the bioinspired patch high potential in biomedical applications.

摘要

补丁在临床医学中起着重要的作用，因为它在组织修复和再生方面有着广泛的应用。在这里，受生物界面中多种粘附、抗粘附和响应结构颜色现象的启发，我们提出了一种混合水凝胶膜，该水凝胶膜具有粘附性的聚多巴胺 (PDA) 层和抗粘附性的聚乙二醇二丙烯酸酯 (PEGDA) 层，形成了一种反蛋白石支架。结果表明，所得水凝胶膜可用作功能性组织贴片，其一个表面具有优异的粘附性能，可用于修复受伤组织，另一个表面具有抗粘附性能，可防止不良粘连。此外，由于响应结构颜色，贴片具有自报告机械性能，可以提供实时的颜色感应反馈来监测心跳活动。此外，PDA 上的儿茶酚基团赋予贴片在体内具有高组织粘附性和自修复能力。这些特性使这种仿生贴片在生物医学应用中具有很高的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/71d7b790e37a/aax8258-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/e0bf35e1689c/aax8258-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/f277eb7c7acc/aax8258-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/24ac489e59a2/aax8258-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/45371b48bcd8/aax8258-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/fdb72cba16d6/aax8258-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/71d7b790e37a/aax8258-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/e0bf35e1689c/aax8258-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/f277eb7c7acc/aax8258-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/24ac489e59a2/aax8258-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/45371b48bcd8/aax8258-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/fdb72cba16d6/aax8258-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51d/6981080/71d7b790e37a/aax8258-F6.jpg

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本文引用的文献

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Adv Mater. 2018-5-29

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