星形胶质细胞和小胶质细胞：在疾病与健康中。
Astrocytes and Microglia: In Sickness and in Health.
机构信息
Department of Psychiatry/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Department of Psychiatry/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
出版信息
Trends Neurosci. 2020 Mar;43(3):144-154. doi: 10.1016/j.tins.2020.01.003. Epub 2020 Feb 7.
Abstract
Healthy central nervous system (CNS) development and function require an intricate and balanced bidirectional communication between neurons and glia cells. In this review, we discuss the complementary roles of astrocytes and microglia in building the brain, including in the formation and refinement of synapses. We discuss recent evidence demonstrating how these interactions are coordinated in the transition from healthy physiology towards disease and discuss known and potential molecular mechanisms that mediate this cellular crosstalk.
摘要
健康的中枢神经系统（CNS）的发育和功能需要神经元和神经胶质细胞之间复杂而平衡的双向通信。在这篇综述中，我们讨论了星形胶质细胞和小胶质细胞在构建大脑中的互补作用，包括在突触的形成和细化中的作用。我们讨论了最近的证据，证明了这些相互作用在从健康生理到疾病的转变中是如何协调的，并讨论了介导这种细胞串扰的已知和潜在的分子机制。
相似文献
1
Astrocytes and Microglia: In Sickness and in Health.星形胶质细胞和小胶质细胞：在疾病与健康中。
Trends Neurosci. 2020 Mar;43(3):144-154. doi: 10.1016/j.tins.2020.01.003. Epub 2020 Feb 7.
2
Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells.从星形胶质细胞到小胶质细胞和少突胶质细胞谱系细胞，胶质细胞与神经元突触的相互作用。
Glia. 2023 Jun;71(6):1383-1401. doi: 10.1002/glia.24343. Epub 2023 Feb 17.
3
Bidirectional Communication Between Microglia and Astrocytes in Neuroinflammation.神经炎症中小胶质细胞与星形胶质细胞的双向通讯。
Curr Neuropharmacol. 2023;21(10):2020-2029. doi: 10.2174/1570159X21666221129121715.
4
The Crosstalk Between Neurons and Glia in Methamphetamine-Induced Neuroinflammation.甲基苯丙胺诱导的神经炎症中神经元与神经胶质细胞之间的相互作用
Neurochem Res. 2022 Apr;47(4):872-884. doi: 10.1007/s11064-021-03513-9. Epub 2022 Jan 4.
5
The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS.“四联体”突触：发育和成熟中枢神经系统中的小胶质细胞-突触相互作用。
Glia. 2013 Jan;61(1):24-36. doi: 10.1002/glia.22389. Epub 2012 Jul 24.
6
[Synaptic phagocytosis by multiple glial cell types].[多种神经胶质细胞类型的突触吞噬作用]
Nihon Yakurigaku Zasshi. 2023;158(5):348-352. doi: 10.1254/fpj.23004.
7
Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation.小胶质细胞-星形胶质细胞串扰：一种亲密的分子对话。
Neuroscientist. 2019 Jun;25(3):227-240. doi: 10.1177/1073858418783959. Epub 2018 Jun 22.
8
Microglia and the Brain: Complementary Partners in Development and Disease.小胶质细胞与大脑：发育和疾病中的互补伙伴。
Annu Rev Cell Dev Biol. 2018 Oct 6;34:523-544. doi: 10.1146/annurev-cellbio-100616-060509. Epub 2018 Aug 8.
9
Glial Cells and Integrity of the Nervous System.神经胶质细胞与神经系统的完整性
Adv Exp Med Biol. 2016;949:1-24. doi: 10.1007/978-3-319-40764-7_1.
10
Chemokines: Key Molecules that Orchestrate Communication among Neurons, Microglia and Astrocytes to Preserve Brain Function.趋化因子：协调神经元、小胶质细胞和星形胶质细胞之间通讯以维持脑功能的关键分子。
Neuroscience. 2020 Jul 15;439:230-240. doi: 10.1016/j.neuroscience.2019.07.035. Epub 2019 Jul 31.
引用本文的文献
1
The potential relationship between Toxocara canis infection and epilepsy in a rat model.犬弓首蛔虫感染与大鼠模型癫痫之间的潜在关系。
Parasitol Res. 2025 Sep 4;124(9):98. doi: 10.1007/s00436-025-08528-7.
2
Alamandine Rescues Cognitive Impairment and Ameliorates Alzheimer's Disease-Like Neuropathology in APP/PS1 Mice.alamandine可挽救APP/PS1小鼠的认知障碍并改善类似阿尔茨海默病的神经病理学变化。
Neurochem Res. 2025 Aug 25;50(5):277. doi: 10.1007/s11064-025-04531-7.
3
Reactive astrocyte-derived neurotoxicity is mitigated by vitronectin in traumatic brain injury mouse model.在创伤性脑损伤小鼠模型中，玻连蛋白可减轻反应性星形胶质细胞衍生的神经毒性。
IBRO Neurosci Rep. 2025 Jul 19;19:300-306. doi: 10.1016/j.ibneur.2025.07.009. eCollection 2025 Dec.
4
Research progress on immunometabolism and gut microbiota in cryptococcal meningitis: mechanisms and therapeutic implications.隐球菌性脑膜炎中免疫代谢与肠道微生物群的研究进展：机制及治疗意义
Front Neurosci. 2025 Jul 16;19:1622349. doi: 10.3389/fnins.2025.1622349. eCollection 2025.
5
When the Stars Misfire: Astrocytic Dysfunctions in Major Depressive Disorder.当星星失去火力：重度抑郁症中的星形胶质细胞功能障碍
Neurochem Res. 2025 Jul 12;50(4):231. doi: 10.1007/s11064-025-04483-y.
6
From nonalcoholic fatty liver disease to neuroinflammation: the role of chronic systemic inflammation.从非酒精性脂肪性肝病到神经炎症：慢性全身炎症的作用
Metab Brain Dis. 2025 Jul 10;40(6):240. doi: 10.1007/s11011-025-01669-9.
7
The role of probiotics, prebiotics, and postbiotics: cellular and molecular pathways activated on glial cells in Alzheimer's disease.益生菌、益生元及后生元的作用：阿尔茨海默病中胶质细胞激活的细胞及分子途径
Front Neurosci. 2025 Jun 25;19:1598011. doi: 10.3389/fnins.2025.1598011. eCollection 2025.
8
Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease.在衰老和阿尔茨海默病过程中，神经胶质反应与突触功能障碍相关。
Nat Commun. 2025 Jul 1;16(1):5653. doi: 10.1038/s41467-025-60806-1.
9
Induced Pluripotent Stem Cells Derived Cellular Models for Investigating Parkinson's Disease Pathogenesis and Drug Screening.用于研究帕金森病发病机制和药物筛选的诱导多能干细胞衍生细胞模型
Stem Cell Rev Rep. 2025 Oct;21(7):1883-1900. doi: 10.1007/s12015-025-10931-7. Epub 2025 Jun 30.
10
Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform.在基于人诱导多能干细胞的共培养平台中模拟小胶质细胞与星形胶质细胞之间的神经炎症相互作用。
Cell Commun Signal. 2025 Jun 20;23(1):298. doi: 10.1186/s12964-025-02304-x.
本文引用的文献
1
Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.觉醒状态下的去甲肾上腺素信号抑制小鼠视觉皮层小胶质细胞的监视和突触可塑性。
Nat Neurosci. 2019 Nov;22(11):1782-1792. doi: 10.1038/s41593-019-0514-0. Epub 2019 Oct 21.
2
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling.神经元网络活动通过去甲肾上腺素信号控制清醒小鼠小胶质细胞的过程监测。
Nat Neurosci. 2019 Nov;22(11):1771-1781. doi: 10.1038/s41593-019-0511-3. Epub 2019 Oct 21.
3
Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia.在正常发育过程中，视网膜星形胶质细胞的大规模死亡是非凋亡性的，并由小胶质细胞执行。
PLoS Biol. 2019 Oct 18;17(10):e3000492. doi: 10.1371/journal.pbio.3000492. eCollection 2019 Oct.
4
Niche stiffness underlies the ageing of central nervous system progenitor cells.龛位硬度是中枢神经系统祖细胞老化的基础。
Nature. 2019 Sep;573(7772):130-134. doi: 10.1038/s41586-019-1484-9. Epub 2019 Aug 15.
5
Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia.通过 cAMP 调节的丝状伪足，对大脑的纳米级监测：小胶质细胞的作用。
Cell Rep. 2019 Jun 4;27(10):2895-2908.e4. doi: 10.1016/j.celrep.2019.05.010.
6
Microglia: Lifelong patrolling immune cells of the brain.小胶质细胞：大脑中终生巡逻的免疫细胞。
Prog Neurobiol. 2019 Aug;179:101614. doi: 10.1016/j.pneurobio.2019.04.003. Epub 2019 May 7.
7
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.单细胞分辨率下的小鼠和人类小胶质细胞的时空异质性。
Nature. 2019 Feb;566(7744):388-392. doi: 10.1038/s41586-019-0924-x. Epub 2019 Feb 13.
8
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.纤维蛋白原诱导阿尔茨海默病模型中小胶质细胞介导的棘突消除和认知障碍。
Neuron. 2019 Mar 20;101(6):1099-1108.e6. doi: 10.1016/j.neuron.2019.01.014. Epub 2019 Feb 5.
9
Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.脑内细胞类型特异性白细胞介素 1 受体 1 信号转导调节不同的神经免疫活性。
Immunity. 2019 Feb 19;50(2):317-333.e6. doi: 10.1016/j.immuni.2018.12.012. Epub 2019 Jan 22.
10
Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.深度单细胞 RNA 测序揭示小胶质细胞和脑髓系细胞的发育异质性。
Neuron. 2019 Jan 16;101(2):207-223.e10. doi: 10.1016/j.neuron.2018.12.006. Epub 2018 Dec 31.
Zotero 插件