Department of Psychiatry/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Department of Psychiatry/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Trends Neurosci. 2020 Mar;43(3):144-154. doi: 10.1016/j.tins.2020.01.003. Epub 2020 Feb 7.
Healthy central nervous system (CNS) development and function require an intricate and balanced bidirectional communication between neurons and glia cells. In this review, we discuss the complementary roles of astrocytes and microglia in building the brain, including in the formation and refinement of synapses. We discuss recent evidence demonstrating how these interactions are coordinated in the transition from healthy physiology towards disease and discuss known and potential molecular mechanisms that mediate this cellular crosstalk.
健康的中枢神经系统（CNS）的发育和功能需要神经元和神经胶质细胞之间复杂而平衡的双向通信。在这篇综述中，我们讨论了星形胶质细胞和小胶质细胞在构建大脑中的互补作用，包括在突触的形成和细化中的作用。我们讨论了最近的证据，证明了这些相互作用在从健康生理到疾病的转变中是如何协调的，并讨论了介导这种细胞串扰的已知和潜在的分子机制。
