Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.
Institute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.
J Exp Med. 2020 Apr 6;217(4). doi: 10.1084/jem.20190457.
Innate mechanisms in the tumor stroma play a crucial role both in the initial rejection of tumors and in cancer promotion. Here, we provide a concise overview of the innate system in cancer and recent advances in the field, including the activation and functions of innate immune cells and the emerging innate properties and modulatory roles of the fibroblastic mesenchyme. Novel insights into the diverse identities and functions of the innate immune and mesenchymal cells in the microenvironment of tumors should lead to improved anticancer therapies.
肿瘤基质中的先天机制在肿瘤的初始排斥和癌症促进中都起着至关重要的作用。在这里，我们简要概述了癌症中的先天系统以及该领域的最新进展，包括先天免疫细胞的激活和功能，以及成纤维样间质的新兴先天特性和调节作用。对先天免疫和间充质细胞在肿瘤微环境中的不同特性和功能的新认识，应该会促使开发出更好的抗癌疗法。
