McDonald J Tyson, Stainforth Robert, Miller Jack, Cahill Thomas, da Silveira Willian A, Rathi Komal S, Hardiman Gary, Taylor Deanne, Costes Sylvain V, Chauhan Vinita, Meller Robert, Beheshti Afshin
RadBioX Services LLC, Okemos, MI 48864, USA.
Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON K1A-1C1, Canada.
Cancers (Basel). 2020 Feb 7;12(2):381. doi: 10.3390/cancers12020381.
Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth's magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included and approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. We provided a summary of how the GeneLab's rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures.
来自银河宇宙射线（GCR）的电离辐射是影响宇航员在地球磁场保护范围之外执行长期任务时健康的主要风险因素之一。美国国家航空航天局（NASA）的基因实验室项目拥有关于辐射暴露的详细信息，这些信息来自使用动物模型的太空飞行实验，并配有精心策划的剂量测定信息。我们分析了多个与地面和太空飞行辐射研究相关的基因实验室组学数据集，这些研究包括[此处原文缺失具体内容]和[此处原文缺失具体内容]方法。利用了一系列从质子到铁粒子的离子，地面研究的剂量范围为0.1至1.0戈瑞，以及在低地球轨道（LEO）飞行的样本，其总剂量为1.0毫戈瑞至30毫戈瑞。通过该分析，我们能够识别出在太空辐射暴露下，将特定离子与特定生物反应相关联的独特生物特征。例如，我们发现线粒体功能、核糖体组装和免疫途径的变化是剂量的函数。我们总结了如何利用基因实验室丰富的动物模型组学实验数据库来生成新的假设，以更好地理解银河宇宙射线暴露对人类健康的风险。
