Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Hungary.
Molecules. 2020 Feb 7;25(3):719. doi: 10.3390/molecules25030719.
The microwave (MW)-assisted direct esterification of phenyl--phosphinic acid, transesterification of the alkyl phenyl--phosphinates so obtained, and the similar reaction of dibenzyl phosphite (DBP) were investigated in detail, and the batch accomplishments were translated into a continuous flow operation that, after optimization of the parameters, such as temperature and flow rate, proved to be more productive. Alcoholysis of DBP is a two-step process involving an intermediate phosphite with two different alkoxy groups. The latter species are of synthetic interest, as precursors for optically active reagents.
详细研究了微波辅助的苯膦酸直接酯化、由此得到的烷基金苯膦酸酯的酯交换以及二苄基磷酸酯（DBP）的类似反应，并将分批实验的成果转化为连续流动操作。经过对温度和流速等参数的优化，该连续流动操作被证明更具生产效率。DBP 的醇解是一个两步过程，涉及到具有两个不同烷氧基的中间亚磷酸酯。后者具有合成意义，可作为手性试剂的前体。
