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使用益生菌作为抗生素治疗的补充。

Using Probiotics as Supplementation for Antibiotic Therapy.

机构信息

State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 201100, China.

出版信息

Int J Mol Sci. 2020 Feb 8;21(3):1136. doi: 10.3390/ijms21031136.

Abstract

is a well-known pathogen that is highly prevalent in the world population, and infection is potentially hazardous to humans because of its relationship to various gastrointestinal diseases, such as gastric ulcers, chronic gastritis, and gastric carcinoma. Therefore, the clinical guidelines recommend taking antibiotic therapy to eradicate the pathogen, which usually leads to the desired therapeutic effect. However, some failure cases of this therapy indicate that the increasing antibiotic resistance and side effects may affect the therapeutic effect. Here we propose that using probiotics as supplementation for antibiotic therapy may provide an extra help. Recent studies have shown that probiotic supplementation therapy has promising application prospects; it can enhance the antibiotic effect to achieve a better therapeutic result and maintain the balance of the host gastrointestinal microbiota. In summary, under global conditions of increasing prevalence, probiotic supplementation therapy is worthy of further studies for future clinical application.

摘要

是一种众所周知的病原体,在世界人口中高度流行,感染可能对人类有潜在危害,因为它与各种胃肠道疾病有关,如胃溃疡、慢性胃炎和胃癌。因此,临床指南建议采用抗生素治疗来根除病原体,通常可以达到预期的治疗效果。然而,这种治疗的一些失败案例表明,抗生素耐药性的增加和副作用可能会影响治疗效果。在这里,我们提出使用益生菌作为抗生素治疗的补充可能会提供额外的帮助。最近的研究表明,益生菌补充治疗具有广阔的应用前景;它可以增强抗生素的效果,达到更好的治疗效果,并维持宿主胃肠道微生物群的平衡。总之,在 患病率不断增加的全球条件下,益生菌补充治疗值得进一步研究,以用于未来的临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/7037652/0ac59712520b/ijms-21-01136-g001.jpg

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