Azatyan Vahe, Yessayan Lazar, Shmavonyan Melanya, Melik-Andreasyan Gayane, Perikhanyan Anush, Porkshenyan Kristina
Department of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, Armenia.
Department of Infectious Diseases, Yerevan State Medical University (YSMU), Yerevan, Armenia.
J Infect Dev Ctries. 2019 May 16;13(5.1):69S-74S. doi: 10.3855/jidc.10919.
Oral fluid cytokine levels can vary considerably during the onset of Inflammatory Periodontitis (IP) especially in people with hepatitis C virus (HCV), hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Aim of our study was to evaluate levels of oral cytokines during the onset of IP among HCV, HBV and HIV negative and positive individuals in order to evaluate local immunity state during these infections.
This was a case control study with 3 groups of virally infected individuals and control group. All had IP including control group.
45 patients (51.7%) had HCV, 18 (20.7%) HBV and 24 (27.6%) HIV. For IL-2 we received significant difference for all groups compared with control -2.83; HBV-31.1 (p < 0.001), HCV-25.99 (p < 0.001) and HIV-24.57 (p < 0.001). For IL-10 significant difference was observed between control -0.94 and HCV-3.63 (p = 0.027), HBV-8.38 (15.51) groups (p < 0.001). IL-4 was significantly higher in control group 14.29 compared to HCV 0.2 (p < 0.001) and HIV 0.21 (p = 0.037) group. The adjusted analysis where we consider age as possible confounder revealed that only IL-2 significantly differs for all groups compared with control group: control vs HCV (p = 0.001); control vs HBV (p = 0.024); control vs HIV (p = 0.004).
Evidence for significant differences when comparing oral fluid cytokines of individuals with HCV, HBV and HIV with non-viral individuals was more obvious for IL-2. IL-2 levels were significantly higher in all 3 groups vs non-viral group even when age is confounder.
在炎症性牙周炎（IP）发病期间，口腔液中的细胞因子水平可能会有很大差异，尤其是在丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）和人类免疫缺陷病毒（HIV）感染者中。我们研究的目的是评估HCV、HBV和HIV阴性及阳性个体在IP发病期间口腔细胞因子的水平，以评估这些感染期间的局部免疫状态。
这是一项病例对照研究，包括3组病毒感染个体和1个对照组。所有组均患有IP，包括对照组。
45例患者（51.7%）感染HCV，18例（20.7%）感染HBV，24例（27.6%）感染HIV。对于白细胞介素-2（IL-2），与对照组相比，所有组均有显著差异：对照组为-2.83；HBV组为-31.1（p<0.001），HCV组为-25.99（p<0.001），HIV组为-24.57（p<0.001）。对于白细胞介素-10（IL-10），对照组为-0.94，与HCV组3.63（p=0.027）、HBV组8.38（15.51）之间观察到显著差异（p<0.001）。与HCV组0.2（p<0.001）和HIV组0.21（p=0.037）相比，对照组白细胞介素-4（IL-4）显著更高，为14.29。在将年龄视为可能混杂因素的校正分析中，与对照组相比，仅IL-2在所有组中存在显著差异：对照组与HCV组（p=0.001）；对照组与HBV组（p=0.024）；对照组与HIV组（p=0.004）。
比较HCV、HBV和HIV感染者与非病毒感染者的口腔液细胞因子时，IL-2的显著差异证据更为明显。即使将年龄作为混杂因素，所有3组的IL-2水平均显著高于非病毒组。
