圆锥角膜动态超高速 Scheimpflug 成像角膜变形响应参数的可重复性和再现性。

Repeatability and reproducibility of corneal deformation response parameters of dynamic ultra-high-speed Scheimpflug imaging in keratoconus.

机构信息

From the Department of Ophthalmology (Herber, Raiskup, Pillunat), University Hospital Carl Gustav Carus, TU Dresden, Germany; Humanitas San Pio X Hospital (R. Vinciguerra), Milan, Italy; School of Engineering (R. Vinciguerra, Lopes), University of Liverpool, United Kingdom; Rio de Janeiro Corneal Tomography and Biomechanics Study Group (Lopes, Ambrósio) and the Departments of Ophthalmology, Federal University of São Paulo (Lopes, Ambrósio), and Federal University of the State of Rio de Janeiro (Ambrósio), Brazil; Humanitas Clinical and Research (P. Vinciguerra), Rozzano, and Humanitas University (P. Vinciguerra), Department of Biomedical Sciences, Milan, Italy.

出版信息

J Cataract Refract Surg. 2020 Jan;46(1):86-94. doi: 10.1016/j.jcrs.2019.08.034.

DOI:10.1016/j.jcrs.2019.08.034

PMID:32050237

Abstract

PURPOSE

To assess the repeatability and reproducibility of dynamic corneal response (DCR) parameters obtained by ultra-high-speed Scheimpflug imaging (Corvis ST); in keratoconic patients.

SETTING

Clinics in Germany, Italy, and Brazil.

DESIGN

Prospective, observational study.

METHODS

Patients were examined 3 times using 2 different dynamic Scheimpflug analyzers (Corvis ST) to obtain repeatability and reproducibility. The reliability of intraocular pressure (IOP), biomechanically corrected IOP (bIOP), pachymetry, and DCR parameters were assessed by the coefficient of repeatability, coefficient of variation (CoV), intraclass correlation coefficient (ICC), and within-subject standard deviation (sw).

RESULTS

Ninety-eight eyes from 98 KC patients were included. The sw of the IOP and bIOP did not exceed 1.1 mm Hg. A CoV less than 10% was found in all DCR parameters and had a good to excellent accordance regarding the ICC. The Corvis Biomechanical Index showed an excellent repeatability and interdevice reproducibility of 0.918 and 0.827, respectively. Also, the tomographic biomechanical index showed an excellent repeatability of 3 Corvis ST and Pentacam measurements (ICC = 0.997). With regard to keratoconic severity, a significant increase in the CoV was found between mild and moderate stages compared with the advanced stage. Nevertheless, it did not exceed 10% of the CoV in severe keratoconic eyes.

CONCLUSION

Corvis ST measurements in keratoconic eyes were highly repeatable and reproducible.

摘要

目的

评估应用超广角Scheimpflug 成像仪（Corvis ST）获取的动态角膜反应（DCR）参数的重复性和再现性，该研究对象为圆锥角膜患者。

设置

德国、意大利和巴西的临床中心。

设计

前瞻性观察性研究。

方法

使用 2 种不同的动态 Scheimpflug 分析仪（Corvis ST）对患者进行 3 次检查，以获得重复性和再现性数据。通过重复性系数、变异系数（CoV）、内组相关系数（ICC）和个体内标准差（sw）评估眼压（IOP）、生物力学校正眼压（bIOP）、角膜厚度和 DCR 参数的可靠性。

结果

纳入 98 例圆锥角膜患者的 98 只眼。IOP 和 bIOP 的 sw 未超过 1.1mmHg。所有 DCR 参数的 CoV 均小于 10%，且 ICC 评估结果较好。Corvis 生物力学指数的重复性和不同设备间的再现性分别为 0.918 和 0.827，均极好。此外，断层生物力学指数的 3 次 Corvis ST 和 Pentacam 测量的重复性极好（ICC=0.997）。就圆锥角膜严重程度而言，与晚期相比，轻度和中度阶段的 CoV 显著增加，但仍未超过严重圆锥角膜眼 CoV 的 10%。