Li Yuxin, Tian Lei, Guo Li-Li, Hao Yiran, Jie Ying
Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Front Bioeng Biotechnol. 2022 Apr 13;10:863240. doi: 10.3389/fbioe.2022.863240. eCollection 2022.
To evaluate the repeatability and reproducibility of recalculated dynamic corneal response (DCR) parameters and the biomechanical-compensated intraocular pressure (bIOP) derived from the Corneal Visualization Scheimpflug Technology (Corvis ST), as well as to study the variations of DCR parameters and their relationship with demographic, and ocular characteristics. A total of 544 healthy subjects were recruited in this study and a series of ophthalmological examinations were performed on their right eyes. Three repeated measurements were obtained at 3-min intervals for 291 of the participants to ensure repeatability. A sum of 100 participants was examined twice within 2-h intervals using two different Corvis ST in the reproducibility study. The repeatability and reproducibility of 37 parameters, including 36 DCR parameters and bIOP, were assessed by the coefficient of repeatability (CR), coefficient of variation (CV), intraclass correlation coefficient (ICC), and within-subject standard deviation (sw). Pearson's correlation coefficients and stepwise multivariate linear regression models were performed to investigate whether the DCR parameters were related to demographic and ocular characteristics. Of all the 37 parameters, 34 showed excellent (ICC ≥0.90) or good (ICC ≥0.75) repeatability while 27 of the 37 parameters showed excellent (ICC ≥0.90) or good (ICC ≥0.75) reproducibility. In particular, a CV of less than 20% was found for all DCR parameters and bIOP. A fraction of 14 out of 36 DCR parameters was selected for correlation analysis, based on measurement reliability and clinical relevance in referring to previous literature. Age was negatively associated with the Highest concavity delta arc length (HCdArcL) and peak distance (PD) but it positively correlated with the Whole Eye Movement Max Length (WEMML). Intraocular pressure (IOP) and central corneal thickness (CCT) were negatively associated with the deformation amplitude ratio (DARM) [1 mm], A1 Velocity (A1V), and PD, while positively related to the stiffness parameter at applanation 1 (SP-A1). The bIOP was negatively associated with A1V but positively associated with A2 Velocity (A2V). The anterior chamber volume (ACV) was negatively associated with the pachy slope (PS), WEMML, and SP-A1. The Corvis ST showed good precision for the repeatability and reproducibility of 36 DCR parameters and bIOP parameters in healthy eyes. The IOP, CCT, bIOP, Km, and ACV significantly influenced the DCR parameters of the eyes.
评估重新计算的动态角膜反应（DCR）参数和源自角膜可视化Scheimpflug技术（Corvis ST）的生物力学补偿眼压（bIOP）的可重复性和再现性，并研究DCR参数的变化及其与人口统计学和眼部特征的关系。本研究共招募了544名健康受试者，并对他们的右眼进行了一系列眼科检查。对291名参与者每隔3分钟进行三次重复测量以确保可重复性。在再现性研究中，100名参与者在2小时间隔内使用两台不同的Corvis ST进行了两次检查。通过重复性系数（CR）、变异系数（CV）、组内相关系数（ICC）和受试者内标准差（sw）评估37个参数（包括36个DCR参数和bIOP）的可重复性和再现性。进行Pearson相关系数和逐步多元线性回归模型以研究DCR参数是否与人口统计学和眼部特征相关。在所有37个参数中，34个显示出极佳（ICC≥0.90）或良好（ICC≥0.75）的可重复性，而37个参数中的27个显示出极佳（ICC≥0.90）或良好（ICC≥0.75）的再现性。特别是，所有DCR参数和bIOP的CV均小于20%。根据测量可靠性和参考既往文献的临床相关性，从36个DCR参数中选择了14个进行相关分析。年龄与最大凹陷弧长（HCdArcL）和峰值距离（PD）呈负相关，但与全眼运动最大长度（WEMML）呈正相关。眼压（IOP）和中央角膜厚度（CCT）与变形幅度比（DARM）[1mm]、A1速度（A1V）和PD呈负相关，而与压平1时的刚度参数（SP-A1）呈正相关。bIOP与A1V呈负相关，但与A2速度（A2V）呈正相关。前房容积（ACV）与增厚斜率（PS）、WEMML和SP-A1呈负相关。Corvis ST在健康眼中对36个DCR参数和bIOP参数的可重复性和再现性显示出良好的精度。IOP、CCT、bIOP、Km和ACV对眼睛的DCR参数有显著影响。
