Lin Fang-Yang, Ho Ren-Wen, Yu Hun-Ju, Yang I-Hui, Fang Po-Chiung, Kuo Ming-Tse
Medical Education Department, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 83301, Taiwan.
Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung City 83301, Taiwan.
Diagnostics (Basel). 2024 Jul 18;14(14):1557. doi: 10.3390/diagnostics14141557.
The study aimed to investigate the extended effects and interrelations of corneal biomechanics, corneal optical density (COD), corneal thickness (CT), and intraocular pressure (IOP) following cataract surgery. Sixteen eyes were analyzed prospectively. The Corneal Visualization Scheimpflug Technology (Corvis ST) device assessed corneal biomechanics, while the Pentacam AxL (Pentacam) measured COD and CT. Postoperative data were collected around six months after surgery, with a subgroup analysis of data at nine months. The Pearson correlation was used to examine the relationship between surgical-induced changes in corneal biomechanics and COD. At six months, significant postoperative differences were observed in various biomechanical indices, including uncorrected IOP (IOPuct) and biomechanics-corrected IOP (bIOP). However, many indices lost statistical significance by the nine-month mark, suggesting the reversibility of postoperative corneal changes. Postoperative COD increased at the anterior layer of the 2-6 mm annulus and incision site. The changes in COD correlated with certain biomechanical indices, including maximal (Max) deformative amplitude (DA) and stiffness parameter (SP). In conclusion, despite significant immediate postoperative changes, corneal biomechanics, COD, and IOP experienced a gradual recovery process following cataract surgery. Clinicians should maintain vigilance for any unusual changes during the short-term observation period to detect abnormalities early.
该研究旨在调查白内障手术后角膜生物力学、角膜光学密度（COD）、角膜厚度（CT）和眼内压（IOP）的长期影响及相互关系。对16只眼睛进行了前瞻性分析。角膜可视化Scheimpflug技术（Corvis ST）设备评估角膜生物力学，而Pentacam AxL（Pentacam）测量COD和CT。术后数据在手术后约六个月收集，并对九个月时的数据进行亚组分析。采用Pearson相关性分析来研究手术引起的角膜生物力学变化与COD之间的关系。在六个月时，观察到术后在各种生物力学指标上存在显著差异，包括未矫正眼压（IOPuct）和生物力学矫正眼压（bIOP）。然而，到九个月时，许多指标失去了统计学意义，这表明术后角膜变化具有可逆性。术后COD在2 - 6毫米环带的前层和切口部位增加。COD的变化与某些生物力学指标相关，包括最大（Max）变形幅度（DA）和刚度参数（SP）。总之，尽管术后立即出现显著变化，但白内障手术后角膜生物力学、COD和IOP经历了一个逐渐恢复的过程。临床医生在短期观察期内应警惕任何异常变化，以便早期发现异常情况。
