长链非编码RNA作为肾脏疾病新的诊断和治疗靶点
Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease.
作者信息
Zhou Qin, Chen Wei, Yu Xue-Qing
机构信息
Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
National Health Commission Key Laboratory of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
出版信息
Chronic Dis Transl Med. 2020 Jan 8;5(4):252-257. doi: 10.1016/j.cdtm.2019.12.004. eCollection 2019 Dec.
Abstract
Long non-coding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury (AKI), chronic kidney disease (CKD), and renal cell carcinoma (RCC). Understanding the roles of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic. This review provides an overview of lncRNA characteristics, biological function and discusses specific studies that provide insight into the function and potential application of lncRNAs in kidney disease treatment.
摘要
长链非编码RNA（lncRNAs）在包括肾脏疾病在内的多种疾病发展过程中发挥着关键作用。越来越多的研究表明，lncRNAs参与肾脏发育，其失调可导致不同的疾病进程，包括急性肾损伤（AKI）、慢性肾脏病（CKD）和肾细胞癌（RCC）。了解lncRNAs在肾脏疾病中的作用可能为临床提供新的诊断和治疗机会。本综述概述了lncRNA的特征、生物学功能，并讨论了一些具体研究，这些研究有助于深入了解lncRNAs在肾脏疾病治疗中的功能及潜在应用。
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