一种分子识别激活的 DNA 纳米爆破器可实现活细胞中的信号增强成像。

A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells.

机构信息

NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410000, China.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

出版信息

Chem Commun (Camb). 2020 Mar 12;56(21):3131-3134. doi: 10.1039/c9cc09682e.

DOI:10.1039/c9cc09682e

PMID:32055812

Abstract

We propose an aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the DNA nanostructure for imaging of target molecules in living cells. The design principle offers a new paradigm to develop nucleic acid nanocircuits for live-cell study and manipulation.

摘要

我们提出了一种适体连接的 DNA 纳米爆破探针，它可以实现 DNA 纳米结构的分子识别激活解组装，用于活细胞中靶分子的成像。该设计原理为开发用于活细胞研究和操作的核酸纳米电路提供了一种新范例。