Department of Pediatrics, Wilford Hall Ambulatory Surgical Center, 1100 Wilford Hall Loop, Joint Base San Antonio-Lackland, San Antonio, TX, USA.
Department of Surgery, Madigan Army Medical Center, 9040 Jackson Ave, Joint Base Lewis-McChord, Tacoma, WA, USA.
J Autism Dev Disord. 2021 Mar;51(3):849-854. doi: 10.1007/s10803-020-04385-8.
Children referred for audiology evaluation due to speech and language delays represent a neurodevelopmentally high-risk group. The audiology evaluation is a behaviorally-challenging encounter early in the diagnostic process. We assessed interfering behaviors (IB) that complicated completion of audiometry as predictors of autism spectrum disorder (ASD) diagnosis. This retrospective cohort study using the Military Health System electronic medical record included 296 children aged 18 to 71 months. Children who displayed IB had increased odds of receiving an ASD diagnosis compared to those who did not (OR = 5.6, 95% CI 2.6-12.1). Interfering behaviors had a high specificity (81%) and negative predictive value (94%) for ASD. The audiology evaluation may represent an opportunity early in the diagnostic process to stratify risk for ASD.
由于言语和语言发育迟缓而转介进行听力学评估的儿童代表了一个神经发育高风险群体。听力学评估是诊断过程中早期具有挑战性的行为评估。我们评估了干扰行为（IB），这些行为会影响听力学测试的完成，并将其作为自闭症谱系障碍（ASD）诊断的预测指标。这项使用军事医疗系统电子病历的回顾性队列研究纳入了 296 名 18 至 71 个月大的儿童。与没有干扰行为的儿童相比，有干扰行为的儿童患 ASD 的几率更高（OR=5.6，95%CI 2.6-12.1）。干扰行为对 ASD 的特异性（81%）和阴性预测值（94%）均较高。听力学评估可能代表了诊断过程早期分层 ASD 风险的机会。
