Cancer Molecular Pathology of School of Medicine, Griffith University, Gold Coast, Queensland, Australia.
Methods Mol Biol. 2020;2129:95-105. doi: 10.1007/978-1-0716-0377-2_8.
Biobanking is important and fundamental for research and personalized medicine in patients with esophageal squamous cell carcinoma. The process often involves prospective collection of surgically obtained tissues (tissue banking) as well as serial blood samples (liquid biopsies) from the patients with esophageal squamous cell carcinoma. Apart from frozen tissues, formalin-fixed paraffin-embedded tissues are important sources of translational research. Careful planning and selection of the region of the paraffin-embedded tissues will maximize the use of tissue for molecular studies. Both cancer and non-cancer samples (controls) could be collected. The success and sustainability of the process needs proper infrastructure, advanced planning, funding, and multidisciplinary collaborations. The understanding of the principles and issues are detrimental for the success of biobanking. The technical procedures involved are standardized, complex, and time-consuming and needs coordinated taskforce.
生物样本库对于食管鳞癌患者的研究和个性化医学非常重要和基础。该过程通常涉及前瞻性收集手术获得的组织（组织库）以及来自食管鳞癌患者的连续血液样本（液体活检）。除了冷冻组织外，福尔马林固定石蜡包埋组织也是转化研究的重要来源。仔细规划和选择石蜡包埋组织的区域将最大限度地提高组织在分子研究中的利用。可以收集癌症和非癌症样本（对照）。该过程的成功和可持续性需要适当的基础设施、先进的规划、资金和多学科合作。了解这些原则和问题对于生物样本库的成功至关重要。所涉及的技术程序是标准化的、复杂的和耗时的，需要协调的工作组。
