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新冠病毒(SARS-CoV-2)的潜伏期是否比 SARS 和 MERS 更长?

Does SARS-CoV-2 has a longer incubation period than SARS and MERS?

机构信息

The Joint Center of Translational Precision Medicine Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China.

The Joint Center of Translational Precision Medicine, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

出版信息

J Med Virol. 2020 May;92(5):476-478. doi: 10.1002/jmv.25708. Epub 2020 Feb 24.

Abstract

The outbreak of a novel coronavirus (SARS-CoV-2) since December 2019 in Wuhan, the major transportation hub in central China, became an emergency of major international concern. While several etiological studies have begun to reveal the specific biological features of this virus, the epidemic characteristics need to be elucidated. Notably, a long incubation time was reported to be associated with SARS-CoV-2 infection, leading to adjustments in screening and control policies. To avoid the risk of virus spread, all potentially exposed subjects are required to be isolated for 14 days, which is the longest predicted incubation time. However, based on our analysis of a larger dataset available so far, we find there is no observable difference between the incubation time for SARS-CoV-2, severe acute respiratory syndrome coronavirus (SARS-CoV), and middle east respiratory syndrome coronavirus (MERS-CoV), highlighting the need for larger and well-annotated datasets.

摘要

自 2019 年 12 月以来,位于中国中部的主要交通枢纽武汉市爆发了一种新型冠状病毒(SARS-CoV-2),这成为国际社会关注的紧急事件。虽然已经有几项病因学研究开始揭示这种病毒的具体生物学特征,但仍需要阐明其流行特征。值得注意的是,据报道,SARS-CoV-2 感染的潜伏期较长,这导致了筛查和控制政策的调整。为了避免病毒传播的风险,所有潜在的接触者都需要被隔离 14 天,这是最长的预测潜伏期。然而,根据我们对迄今为止可用的更大数据集的分析,我们发现 SARS-CoV-2、严重急性呼吸综合征冠状病毒(SARS-CoV)和中东呼吸综合征冠状病毒(MERS-CoV)的潜伏期没有明显差异,这凸显了需要更大且有良好注释的数据集。

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