School of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China.
School of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China.
Colloids Surf B Biointerfaces. 2020 May;189:110848. doi: 10.1016/j.colsurfb.2020.110848. Epub 2020 Feb 5.
Some additives had provided the expansion capacity to the polymethylmethacrylate (PMMA) bone cement and also reduced its maximum reaction temperature. However, the corresponding modified bone cement displayed inferior simulated body fluid (SBF) absorption capacity and expansion behavior, the mechanism of SBF absorption and the trend of expansion stress were ignored additionally. In this study, a homogeneous distribution of poly (methyl methacrylate-co-acrylic acid) [P(MMA-AA)] microspheres led to the formation of microchannels that favored the delivery of SBF to the interior, causing an increased absorption capacity and enhanced expansion behavior before solidification of the bone cement, with the maximum equilibrium absorption ratio and the expansion ratio reaching 27.3 % and 26.3 %, respectively, at an AA content of 50 %. In addition, the expansion stress induced by the expansion behavior experienced a gradual increase from the 0 s to 2590s, followed by a sharp climbed in a short period ranging from 2590s to 2900s, finally reaching maximum stress of 82.1 MPa. Furthermore, the expansion stress within the maximum value could be obtained by controlling the AA content in the P(MMA-AA) bone cement. With the above characteristics, the prepared P(MMA-AA) bone cement has potential applications as a filling and adhesive material in arthroplasties, vertebroplasties, joint replacements, bone screws, and dentistry.
一些添加剂为聚甲基丙烯酸甲酯（PMMA）骨水泥提供了膨胀能力，同时降低了其最高反应温度。然而，相应的改性骨水泥显示出较差的模拟体液（SBF）吸收能力和膨胀行为，此外还忽略了 SBF 吸收的机制和膨胀应力的趋势。在这项研究中，聚（甲基丙烯酸甲酯-丙烯酸）[P（MMA-AA）]微球的均匀分布导致微通道的形成，有利于 SBF 输送到内部，从而在骨水泥凝固之前提高吸收能力和增强膨胀行为，在 AA 含量为 50%时，最大平衡吸收比和膨胀比分别达到 27.3%和 26.3%。此外，膨胀行为引起的膨胀应力从 0 s 逐渐增加到 2590 s，然后在 2590 s 到 2900 s 之间的短时间内急剧攀升，最终达到 82.1 MPa 的最大应力。此外，通过控制 P（MMA-AA）骨水泥中 AA 的含量，可以获得最大膨胀应力值内的膨胀应力。具有上述特点的 P（MMA-AA）骨水泥有望作为关节置换、椎体成形术、关节置换、骨螺钉和牙科的填充和胶粘剂材料应用。
