University of Texas Southwestern Medical Center, Dallas, Texas;, Email:
Mississippi State University, Starkville, Mississippi.
J Am Assoc Lab Anim Sci. 2020 Mar 1;59(2):127-131. doi: 10.30802/AALAS-JAALAS-19-000096. Epub 2020 Feb 14.
Introduced over 20 y ago, IACUCs undertaking postapproval monitoring (PAM) of animal research procedures as a means to ensure researcher compliance is now widely used as an oversight tool in laboratory animal research. Through a literature review evaluating the history of PAM in the United States, discussions of controversy surrounding PAM activities, and reflections on how PAM activities are described within the IACUC community, we present an up-to-date and comprehensive classification system for PAM program methodologies that could serve to standardize how such activities are characterized in IACUC policies, communicated to research staff, used in training programs, implemented for the desired impact by individuals involved in animal research oversight, and referenced by regulatory agencies.
引入 20 多年前，IACUC 委员会承担动物研究程序的批准后监测（PAM），作为确保研究人员合规的一种手段，现在已广泛用作实验室动物研究的监督工具。通过对美国 PAM 历史的文献回顾，对 PAM 活动争议的讨论，以及对 IACUC 社区内如何描述 PAM 活动的反思，我们提出了一个最新和全面的 PAM 计划方法分类系统，该系统可以用来标准化 IACUC 政策中此类活动的特征，传达给研究人员，用于培训计划，由参与动物研究监督的个人实施以产生预期影响，并由监管机构参考。
