Department of Animal Medicine and Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts.
Yale Animal Resources Center and Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
Lab Anim (NY). 2017 Mar 22;46(4):129-135. doi: 10.1038/laban.1213.
There is a "village" of people impacting research reproducibility, such as funding panels, the IACUC and its support staff, institutional leaders, investigators, veterinarians, animal facilities, and professional journals. IACUCs can contribute to research reproducibility by ensuring that reviews of animal use requests, program self-assessments and post-approval monitoring programs are sufficiently thorough, the animal model is appropriate for testing the hypothesis, animal care and use is conducted in a manner that is compliant with external and institutional requirements, and extraneous variables are minimized. The persons comprising the village also must have a shared vision that guards against reproducibility problems while simultaneously avoids being viewed as a burden to research. This review analyzes and discusses aspects of the IACUC's "must do" and "can do" activities that impact the ability of a study to be reproduced. We believe that the IACUC, with support from and when working synergistically with other entities in the village, can contribute to minimizing unintended research variables and strengthen research reproducibility.
有一个“村落”的人在影响研究的可重复性，如资助小组、IACUC 及其支持人员、机构领导、研究人员、兽医、动物设施和专业期刊。IACUC 可以通过确保对动物使用请求的审查、计划自我评估和批准后监测计划进行充分的审查，确保动物模型适合测试假设，以符合外部和机构要求的方式进行动物护理和使用，以及最小化额外变量，来促进研究的可重复性。构成这个村落的人也必须有一个共同的愿景，既要防止可重复性问题，又要避免被视为研究的负担。这篇综述分析和讨论了 IACUC“必须做”和“可以做”的活动，这些活动影响了研究的可重复性。我们相信，IACUC 在得到村落中其他实体的支持并与其协同工作的情况下，可以帮助最小化意外的研究变量，并加强研究的可重复性。
