Norton John N, Reynolds Randall P, Chan Cliburn, Valdivia Raphael H, Staats Herman F
Division of Laboratory Animal Resources, Duke University Medical Center, Durham, North Carolina, USA;
Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
FASEB J. 2017 Sep;31(9):3913-3921. doi: 10.1096/fj.201700072RR. Epub 2017 May 17.
Although animal research requires adherence to various regulations and standards, the manner in which compliance is maintained and the degree of additional constraints varies between institutions. Regulatory burden, particularly if institutionally imposed, has become a concern for institutions as increased regulatory expectations result in decreased resources available for research efforts. Faculty, research staff, and support staff engaged in animal research were surveyed to determine what institutional animal care and use committee (IACUC) processes were considered burdensome, the perceived value of some suggested modifications, and satisfaction with the IACUC administrative office and the animal resource unit. Although the results revealed overwhelming satisfaction with the IACUC administrative office and the animal resource unit, several IACUC processes were deemed burdensome, and therefore there would be value in modifying IACUC processes. When comparing the value of modifying IACUC processes, different groups within the animal care and use program (ACUP) tended to have different responses on many of the topics. This survey identified several perceived burdensome IACUC processes that would likely benefit individuals if modified. In today's environment of shrinking budgets for biomedical research, minimizing regulatory burden-particularly unnecessary, self-imposed burden-in the ACUP is particularly important to ensure that costs, time, and effort are appropriate to achieve animal welfare and quality of research endeavors.-Norton, J. N., Reynolds, R. P., Chan, C., Valdivia, R. H., Staats, H. F. Assessing the satisfaction and burden within an academic animal care and use program.
尽管动物研究需要遵守各种法规和标准,但各机构在维持合规的方式以及额外限制的程度方面存在差异。监管负担,尤其是机构自行施加的监管负担,已成为各机构关注的问题,因为监管期望的提高导致可用于研究工作的资源减少。对从事动物研究的教师、研究人员和支持人员进行了调查,以确定哪些机构动物护理和使用委员会(IACUC)流程被认为是繁重的,一些建议修改的感知价值,以及对IACUC行政办公室和动物资源单位的满意度。尽管结果显示对IACUC行政办公室和动物资源单位的满意度极高,但一些IACUC流程被认为是繁重的,因此修改IACUC流程是有价值的。在比较修改IACUC流程的价值时,动物护理和使用计划(ACUP)中的不同群体在许多主题上往往有不同的反应。这项调查确定了几个被认为繁重的IACUC流程,如果进行修改,可能会使个人受益。在当今生物医学研究预算不断缩减的环境下,尽量减少ACUP中的监管负担,尤其是不必要的自我施加的负担,对于确保成本、时间和精力与实现动物福利和研究工作质量相适应尤为重要。——诺顿,J.N.,雷诺兹,R.P.,陈,C.,瓦尔迪维亚,R.H.,施塔茨,H.F.评估学术动物护理和使用计划中的满意度和负担。