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综合和比较协作创始菌株的表型分析确定了新的和已知的表型。

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.

机构信息

Department of Infection Genetics, Helmholtz Centre for Infection Research, Inhoffenstr.7, 38124, Braunschweig, Germany.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.

出版信息

Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14.

DOI:10.1007/s00335-020-09827-3
PMID:32060626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7060152/
Abstract

The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.

摘要

合作交叉 (CC) 是由八个创始品系（NOD/ShiLtJ、NZO/HILtJ、A/J、C57BL/6J、129S1/SvImJ、CAST/EiJ、PWK/PhJ 和 WSB/EiJ）衍生而来的大型小鼠近交系面板。在这里，我们进行了全面和比较表型筛选，以确定八个创始品系之间的表型差异和相似性。总共分析了超过 300 个参数，包括过敏、行为、心血管、临床血液化学、畸形、骨骼和软骨、能量代谢、眼睛和视力、免疫学、肺功能、神经学、痛觉和病理学；在来自 16 只雌性和 16 只雄性的大多数特征中。我们确定了 270 多个参数在品系之间存在显著差异。这项研究强调了创始和 CC 品系在与人类疾病高度相关的许多遗传特征的表型-基因型关联中的价值。这里描述的所有数据都可从小鼠表型数据库中公开获取，用于分析和下载。

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