Fekadu M
Division of Viral Diseases, Centers for Disease Control, Lawrenceville, Georgia 30246-0363.
Rev Infect Dis. 1988 Nov-Dec;10 Suppl 4:S678-83. doi: 10.1093/clinids/10.supplement_4.s678.
Most dogs experimentally infected with street rabies virus showed clinical signs of rabies before death, but up to 18% of the dogs died without showing detectable signs of illness. In dogs showing signs, rabies was not invariably fatal. Up to 20% of dogs recovered without any supportive treatment. Some dogs inoculated with American (southern Texas) or Ethiopian canine street virus excreted virus in their saliva up to 14 days before signs appeared. There was no relation between the time of excretion of virus in the saliva and the titer of virus in the salivary glands at death. One dog that recovered from rabies intermittently excreted rabies virus in its saliva for a long time. The carrier state in rabies may play a significant role in the perpetuation and survival of the virus and may become a source for rabies outbreaks whenever a new generation of rabies susceptibles reaches critical density.
大多数经实验感染街狂犬病毒的犬只在死亡前出现狂犬病临床症状，但高达18%的犬只在未表现出可检测到的疾病迹象的情况下死亡。在出现症状的犬只中，狂犬病并非总是致命的。高达20%的犬只在没有任何支持性治疗的情况下康复。一些接种了美国（得克萨斯州南部）或埃塞俄比亚犬街病毒的犬只在出现症状前14天内在唾液中排出病毒。唾液中病毒排出时间与死亡时唾液腺中病毒滴度之间没有关系。一只从狂犬病中康复的犬只在很长一段时间内间歇性地在唾液中排出狂犬病毒。狂犬病的携带状态可能在病毒的持续存在和存活中发挥重要作用，并且每当新一代狂犬病易感动物达到临界密度时，可能成为狂犬病爆发的源头。
