Institute of Health and Biological Sciences (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil.
Professor, Department of Anatomy, Biosciences Center (CB), Federal University of Pernambuco (UFPE), Recife, PE, Brazil.
Oral Oncol. 2020 Mar;102:104524. doi: 10.1016/j.oraloncology.2019.104524. Epub 2020 Feb 13.
Oral Mucositis is a frequent and debilitating inflammatory complication in patients with head and neck malignancies and may lead to unplanned treatment interruptions due to intense pain and dysphagia. This systematic review with meta-analysis was performed to determine the effectiveness of low-level laser therapy in preventing oral mucositis in this context. The following databases were searched through September 2018, with last search performed on May 2019, for clinical trials: MEDLINE via PubMed, Cochrane Central, Scopus, Lilacs, ISI Web of Science and SIGLE via Open Grey. From 14,525 records, 4 studies were included in the review and 3 studies were included in meta-analysis. Data from 500 patients (mean age of 53.595 and 54.14 for intervention and control groups, respectively) were analysed. Meta-analysis showed that laser therapy prevents oral mucositis incidence in 28% and 23% of cases during the third and fourth follow-up week, respectively, in comparison to a placebo-treated control group. There was no statistically significant difference the prevention of pain; dysphagia and quality of life were not analysed due to missing. Laser therapy was effective in preventing oral mucositis from the 15th to the 45th days of chemoradiotherapy. However, new primary studies with low risk of bias are needed so a higher scientific evidence can be obtained.
口腔黏膜炎是头颈部恶性肿瘤患者常见且使人虚弱的炎症并发症，可能因剧烈疼痛和吞咽困难而导致治疗计划中断。本系统评价和荟萃分析旨在确定低水平激光疗法在预防这种情况下口腔黏膜炎方面的有效性。通过以下数据库检索了截至 2018 年 9 月的临床试验：PubMed 中的 MEDLINE、Cochrane 中央、Scopus、Lilacs、ISI Web of Science 和 Open Grey 中的 SIGLE。从 14525 条记录中，有 4 项研究被纳入了综述，有 3 项研究被纳入了荟萃分析。分析了 500 名患者的数据（干预组和对照组的平均年龄分别为 53.595 岁和 54.14 岁）。荟萃分析显示，与安慰剂对照组相比，激光疗法可分别在第 3 周和第 4 周的随访中预防 28%和 23%的口腔黏膜炎发生。在预防疼痛方面无统计学差异；由于缺乏数据，未分析吞咽困难和生活质量。在放化疗的第 15 至 45 天，激光疗法可有效预防口腔黏膜炎。然而，需要新的低偏倚风险的原始研究，以获得更高的科学证据。
