Specialist Medical Centre Periomed Przemysław Jabłoński, 42-100 Klobuck, Poland.
Department of Orthodontics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Medicina (Kaunas). 2022 Apr 29;58(5):618. doi: 10.3390/medicina58050618.
In 2021, our group published a laboratory study on the impact of PBM on human gingival fibroblasts. The in vitro results confirmed the fact that the appropriately selected wavelength and properly selected parameters of the laser settings can increase cell proliferation, modulate inflammatory markers, and decrease the susceptibility of human gingival fibroblasts to apoptosis. Therefore, this case report was aimed at the clinical evaluation of the proposed settings and treatment regimen in a very difficult situation of an immunocompromised patient with extensive changes and stagnation of symptoms for many weeks. A 65-year-old man, during his oncological treatment, was diagnosed with oral mucositis grade 3 according to the World Health Organization and National Cancer Institute scales. Due to pain sensation, long-lasting and not healing oral lesions, and problems with solid food intake, he was qualified for laser photobiomodulation therapy. For the management of oral lesions, a diode laser 635 nm (SmartPro, Lasotronix, Poland) was intraorally applied at an energy density of 4 J/cm, the 20 s of irradiation, the output power of 100 mW, and in continuous wave mode. Seven treatment procedures were performed two times a week using the spot technique in contact and non-contact mode. Within 21 days of monotherapy, all ailments disappeared. The patient was also able to reuse dental dentures and return to a solid diet. The obtained results confirm the efficiency of at least 3 PBM protocols. Our case shows that the use of PMB therapy contributes to faster healing of painful oral lesions in oncological patients, and thus the treatment time and return to the appropriate quality of life is shorter.
2021 年，我们小组发表了一项关于 PBM 对人牙龈成纤维细胞影响的实验室研究。体外研究结果证实，适当选择波长和适当选择激光参数可以增加细胞增殖、调节炎症标志物、降低人牙龈成纤维细胞对凋亡的敏感性。因此，本病例报告旨在评估在免疫功能低下患者的非常困难情况下，提出的设置和治疗方案，该患者症状广泛改变且持续数周无改善。一名 65 岁男性在接受肿瘤治疗期间，根据世界卫生组织和美国国立癌症研究所的标准，被诊断为口腔黏膜炎 3 级。由于存在疼痛感觉、持续且未愈合的口腔病变以及固体食物摄入问题，他有资格接受激光光生物调节治疗。为了管理口腔病变，使用二极管激光 635nm（SmartPro，Lasotronix，波兰）以 4J/cm 的能量密度、20 秒的辐照时间、100mW 的输出功率和连续波模式进行口腔内应用。每周两次使用接触和非接触点技术进行 7 次治疗。在单独治疗 21 天内，所有不适症状均消失。患者还能够重新使用牙托并恢复正常的固体饮食。获得的结果证实了至少 3 种 PBM 方案的有效性。我们的病例表明，PMB 治疗可促进肿瘤患者疼痛性口腔病变更快愈合，从而缩短治疗时间并恢复适当的生活质量。
