Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; Biomedicine Program, Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain.
Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Clin Nutr. 2020 Oct;39(10):3092-3098. doi: 10.1016/j.clnu.2020.01.015. Epub 2020 Feb 3.
There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are overweight or obese.
This prospective study included 489 men and women, aged 55-75 years, from the PREDIMED-Plus trial. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES) were obtained from fasting blood samples and a composite inflammatory score based on these biomarkers was calculated. Physical activity was measured by a validated questionnaire. All measures were taken at baseline and one-year follow-up.
Multiple linear regression models showed an association between an increase in total PA and a decrease in the inflammatory score (p = 0.012), which was particularly driven by a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006).
Increases in total PA, moderate and moderate-to-vigorous PA were associated with a decrease in the inflammatory profile of obese or overweight older individuals. This finding is relevant for PA recommendations and public health strategies.
Clinical trial identifier: International Standard Randomized Controlled Trial 89898870.
关于体力活动（PA）与老年人炎症之间的关联，前瞻性证据有限。我们的目的是评估超重或肥胖的老年人 PA 变化与炎症特征变化之间的关联。
本前瞻性研究纳入了来自 PREDIMED-Plus 试验的 489 名年龄在 55-75 岁的男性和女性。从空腹血样中获得白细胞介素 6（IL-6）、白细胞介素 8（IL-8）、白细胞介素 18（IL-18）、单核细胞趋化蛋白-1（MCP-1）、C 肽、高敏 C 反应蛋白（hs-CRP）、瘦素和活化正常 T 细胞表达和分泌趋化因子（RANTES）的水平，并基于这些生物标志物计算综合炎症评分。通过经过验证的问卷来测量体力活动。所有措施均在基线和一年随访时进行。
多元线性回归模型显示，总 PA 的增加与炎症评分的降低呈相关（p=0.012），这主要是由 C 肽的降低驱动的（p=0.037）。同样，随着中等强度 PA（p=0.001）和中等强度至高强度 PA（p=0.006）的增加，炎症评分也随之降低。
总 PA、中等强度和中高强度 PA 的增加与肥胖或超重老年人炎症特征的降低相关。这一发现与 PA 推荐和公共卫生策略有关。
临床试验标识符：国际标准随机对照试验 89898870。
