Singh Anirudha, Zhan Jianan, Ye Zhaoyang, Elisseeff Jennifer H
400 N. Broadway, Robert H. & Clarice Smith Building, Wilmer Eye Institute & Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD-21231, USA.
The State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, Shanghai-200237, China.
Adv Funct Mater. 2013 Feb 5;23(5):575-582. doi: 10.1002/adfm.201201902. Epub 2012 Sep 13.
Synthetic polymers are employed to create highly defined microenvironments with controlled biochemical and biophysical properties for cell culture and tissue engineering. Chemical modification is required to input biological or chemical ligands, which often changes the fundamental structural properties of the material. Here, we report on a simple modular biomaterial design strategy that employs functional cyclodextrin nanobeads threaded onto poly(ethylene glycol) polymer necklaces to form multifunctional hydrogels. Nanobeads with desired chemical or biological functionalities can be simply threaded onto the PEG chains to form hydrogels, creating an accessible platform for users. We describe the design and synthesis of these multifunctional hydrogels, elucidate structure-property relationships, and demonstrate applications ranging from stem cell culture and differentiation to tissue engineering.
合成聚合物被用于创建具有可控生化和生物物理特性的高度明确的微环境，用于细胞培养和组织工程。需要进行化学修饰以引入生物或化学配体，这通常会改变材料的基本结构特性。在此，我们报告一种简单的模块化生物材料设计策略，该策略利用连接在聚乙二醇聚合物链上的功能性环糊精纳米珠来形成多功能水凝胶。具有所需化学或生物功能的纳米珠可以简单地连接到聚乙二醇链上以形成水凝胶，为用户创建一个易于使用的平台。我们描述了这些多功能水凝胶的设计与合成，阐明了结构与性能的关系，并展示了从干细胞培养与分化到组织工程等一系列应用。
