Zhang Zhaoqiang, Zhuang Lin, Lin Yi, Yan Mengdie, Lv Jiahong, Li Xiaolei, Lin Han, Zhu Ping, Lin Qiuping, Xu Yue
Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Southern Medical University Guangzhou, China.
State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Provincial Key Laboratory of Photovoltaics Technonogies, School of Physics and Engineering, Institute for Solar Energy Systems, Sun Yat-sen University Guangzhou, China.
Am J Cancer Res. 2020 Jan 1;10(1):350-364. eCollection 2020.
Magnetic targeting delivery of anti-cancer drug with controlled drug release function has been recognized as a promising strategy for pursuit of the increased chemotherapeutic efficacy and reduced adverse effects. Superparamagnetic nano-carrier is proved to be an efficient manner for superficial tumor therapy like head and neck cancers. The anti-tumor effect of chemotherapy drug can be enhanced by combining with external magnet. Herein, we reported the fabrication and functionalization of biocompatible and superparamagnetic hollow mesoporous nanoparticles with magnetic targeting. The nanoparticles drug delivery system was constructed by surface-engineering polyacrylic acid (PAA) onto the superparamagnetic nanoparticles which can load bleomycin (BLM) both in the mesoporous structure and via bonding with PAA. The drug was targeted and retained to the focal area under the magnetic field with the nano-carriers, and released sustainably. Detailed investigations demonstrated that PAA-functionalized magnetite nanoparticles loading BLM could stimulate tumor cells to apoptosis locally. The drug loaded and delivery system endowed the anticancer drug with targeting capability and suppressed the growth of tumor . The present targeted drug delivery system is a rather simple method without sophisticated chemistry or materials engineering and is promising in contributing to the progress of nanotherapeutics toward efficient head and neck cancer treatment.
具有药物控释功能的抗癌药物磁靶向递送已被认为是一种有望提高化疗疗效并减少不良反应的策略。超顺磁性纳米载体被证明是治疗头颈部癌等浅表肿瘤的有效方式。化疗药物与外部磁场结合可增强抗肿瘤效果。在此，我们报道了具有磁靶向性的生物相容性超顺磁性中空介孔纳米粒子的制备及其功能化。通过在超顺磁性纳米粒子表面工程化聚丙烯酸（PAA）构建纳米粒子药物递送系统，该系统能够在介孔结构中以及通过与PAA结合来负载博来霉素（BLM）。在磁场作用下，纳米载体将药物靶向并保留在病灶区域，并实现持续释放。详细研究表明，负载BLM的PAA功能化磁铁矿纳米粒子可局部刺激肿瘤细胞凋亡。该载药递送系统赋予抗癌药物靶向能力并抑制肿瘤生长。目前的靶向药物递送系统是一种相当简单的方法，无需复杂的化学或材料工程，有望为纳米治疗在高效治疗头颈部癌方面的进展做出贡献。
