Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 511443, China.
School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Sci Adv. 2019 Dec 20;5(12):eaax4659. doi: 10.1126/sciadv.aax4659. eCollection 2019 Dec.
For early-stage diagnostics, there is a strong demand for sensors that can rapidly detect biomarkers at ultralow concentration or even at the single-molecule level. Compared with other types of sensors, optical microfibers are more convenient for use as point-of-care devices in early-stage diagnostics. However, the relatively low sensitivity strongly hinders their use. To this end, an optical microfiber is functionalized with a plasmonic nanointerface consisting of black phosphorus-supported Au nanohybrids. The microfiber is able to detect epidermal growth factor receptor (ErbB2) at concentrations ranging from 10 zM to 100 nM, with a detection limit of 6.72 zM, enabling detection at the single-molecule level. The nanointerface-sensitized microfiber is capable of differentiating cancer cells from normal cells and treating cancer cells through cellular photothermal therapy. This work opens up a possible approach for the integration of cellular diagnosis and treatment.
对于早期诊断，人们强烈需求能够快速检测超低浓度甚至单分子水平生物标志物的传感器。与其他类型的传感器相比，光学微光纤作为早期诊断的即时诊断设备更为方便。然而，相对较低的灵敏度严重阻碍了它们的应用。为此，一种等离子体纳米界面由负载黑磷的金纳米杂化物组成，对光学微光纤进行功能化。该微光纤能够检测浓度范围为 10 zM 至 100 nM 的表皮生长因子受体 (ErbB2)，检测限为 6.72 zM，实现了单分子水平的检测。纳米界面敏化的微光纤能够区分癌细胞和正常细胞，并通过细胞光热疗法治疗癌细胞。这项工作为细胞诊断和治疗的整合开辟了一条可能的途径。
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