Max Planck Institute for the Science of Light, Staudtstrabe 2, 91058 Erlangen, Germany.
Lab Chip. 2017 Mar 29;17(7):1190-1205. doi: 10.1039/c6lc01595f.
Whispering gallery mode biosensors have been widely exploited over the past decade to study molecular interactions by virtue of their high sensitivity and applicability in real-time kinetic analysis without the requirement to label. There have been immense research efforts made for advancing the instrumentation as well as the design of detection assays, with the common goal of progressing towards real-world sensing applications. We therefore review a set of recent developments made in this field and discuss the requirements that whispering gallery mode label-free sensors need to fulfill for making a real world impact outside of the laboratory. These requirements are directly related to the challenges that these sensors face, and the methods proposed to overcome them are discussed. Moving forward, we provide the future prospects and the potential impact of this technology.
whispering gallery mode 生物传感器在过去十年中得到了广泛的应用，通过其高灵敏度和实时动力学分析的适用性，无需标记即可研究分子相互作用。人们为推进仪器仪表以及检测分析的设计做出了巨大的研究努力，其共同目标是朝着实际传感应用的方向发展。因此，我们综述了该领域的一组最新进展，并讨论了 whispering gallery mode 无标记传感器需要满足的要求，以便在实验室之外对现实世界产生影响。这些要求与这些传感器面临的挑战直接相关，并讨论了克服这些挑战的方法。展望未来，我们提供了这项技术的未来前景和潜在影响。
