School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia.
Benef Microbes. 2020 Feb 19;11(1):79-89. doi: 10.3920/BM2019.0086. Epub 2020 Jan 14.
Alzheimer's disease (AD) is a progressive disease and one of the most common forms of neurodegenerative disorders. Emerging evidence is supporting the use of various strategies that modulate gut microbiota to exert neurological and psychological changes. This includes the utilisation of probiotics as a natural and dietary intervention for brain health. Here, we showed the potential AD-reversal effects of probiotics through feeding to our AD model. The administration of strains was able to rescue the rough eye phenotype (REP) seen in AD-induced , with a more prominent effect observed upon the administration of DR7 (DR7). Furthermore, we analysed the gut microbiota of the AD-induced and found elevated levels of . The administration of DR7 restored the gut microbiota diversity of AD-induced with a significant reduction in 's relative abundance, accompanied by an increase of and . Through functional predictive analyses, was predicted to be positively correlated with neurodegenerative disorders, such as Parkinson's, Huntington's and Alzheimer's diseases, while was negatively correlated with these neurodegenerative disorders. Altogether, our data exhibited DR7's ability to ameliorate the AD effects in our AD-induced . Thus, we propose that be used as a potential biomarker for AD.
阿尔茨海默病（AD）是一种进行性疾病，也是最常见的神经退行性疾病之一。越来越多的证据支持使用各种调节肠道微生物群的策略来发挥神经和心理变化。这包括利用益生菌作为一种天然的和饮食干预措施来促进大脑健康。在这里，我们通过给 AD 模型喂食展示了益生菌的潜在 AD 逆转作用。施用这些菌株能够挽救 AD 诱导的 中出现的粗糙眼表型（REP），而在施用 DR7（DR7）时观察到更明显的效果。此外，我们分析了 AD 诱导的 中的肠道微生物群，发现 的水平升高。DR7 的施用恢复了 AD 诱导的 肠道微生物群的多样性，显著降低了 's 的相对丰度，同时增加了 和 。通过功能预测分析， 被预测与神经退行性疾病（如帕金森病、亨廷顿病和阿尔茨海默病）呈正相关，而 与这些神经退行性疾病呈负相关。总的来说，我们的数据显示 DR7 能够改善 AD 诱导的 中的 AD 效应。因此，我们提出将 用作 AD 的潜在生物标志物。
