Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Nat Prod Res. 2021 Nov;35(22):4331-4337. doi: 10.1080/14786419.2020.1713121. Epub 2020 Feb 18.
Flowers of have been used for the treatment of inflammation-related diseases in traditional Chinese medicine with limited scientific validation. In the present work, we reported one new rare methyl-flavonoid, plantanone D () and one known compound 4-hydroxybenzoic acid () from the flowers of . Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. To the best of our knowledge, the methyl-flavonoid skeleton have not been reported from any species in Liliaceae family, compound was isolated from the genus for the first time. The anti-inflammatory activities against cyclooxygenases (COX-1 and COX-2) and antioxidant activities results revealed that exhibited significant COX-1 inhibition and moderate COX-2 inhibition compared to the reference celecoxib. Additionally, displayed significant antioxidant activity compared to the positive control L-ascorbic acid.
的花在传统中药中被用于治疗炎症相关疾病，但科学验证有限。在本工作中，我们从的花中报道了一个新的罕见甲基黄酮类化合物，plantanone D（）和一个已知化合物 4-羟基苯甲酸（）。它们的结构是根据化学和光谱证据以及与文献数据的比较来阐明的。据我们所知，甲基黄酮骨架尚未从百合科的任何物种中报道过，化合物 是首次从属中分离得到的。抗炎活性对环氧化酶（COX-1 和 COX-2）和抗氧化活性结果表明，与参比塞来昔布相比，表现出显著的 COX-1 抑制和适度的 COX-2 抑制。此外，与阳性对照 L-抗坏血酸相比，表现出显著的抗氧化活性。
