Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China.
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China.
J Ethnopharmacol. 2020 May 10;253:112685. doi: 10.1016/j.jep.2020.112685. Epub 2020 Feb 23.
The flower of Hosta plantaginea (Lam.) Aschers (Liliaceae) is a traditional medicinal material in Mongolian medicine for treating sore throat, hoarseness, pulmonary fever, and toxic fever in folk. The present work investigated anti-prostate cancer and hepatoprotective activities of flavonoid derivatives from H. plantaginea (Lam.) Aschers.
To isolate and identify the chemicals of H. plantaginea (Lam.) Aschers for anti-prostate cancer and hepatoprotective activities.
Active chemicals were isolated and purified from H. plantaginea (Lam.) Aschers by chromatographic methods, and their structures were established on spectroscopic analysis and references. These compounds were evaluated for their anti-prostate cancer activities using the LNCaP prostate cancer cells, and assayed for their hepatoprotective activities on CCl-induced injury of human L-O2 cells, respectively.
Four new flavonol-lignan heterodimers (1-4), together with nine known flavonoid derivatives (5-13) were isolated from this plant for the first time. Among them, some compounds exhibited moderate anti-prostate cancer and hepatoprotective activities.
Compounds 1, 2, 5, and 6 showed anti-prostate cancer activities using the LNCaP prostate cancer cells with IC values of 17.84, 33.26, 54.13, and 81.55 μg/mL, and compounds 3, 4, 8, and 9 exhibited moderate hepatoprotective activities, respectively. A preliminary structure-activity relation was summarized in this paper.
玉簪属植物的花（Lam.）Aschers（百合科）是蒙药中治疗喉咙痛、声音嘶哑、肺热和毒热的传统药材。本研究调查了玉簪属植物（Lam.）Aschers 的类黄酮衍生物的抗前列腺癌和保肝活性。
从玉簪属植物（Lam.）Aschers 中分离和鉴定具有抗前列腺癌和保肝活性的化学成分。
采用色谱方法从玉簪属植物（Lam.）Aschers 中分离和纯化活性化合物，并通过光谱分析和参考文献确定其结构。这些化合物分别在 LNCaP 前列腺癌细胞中进行抗前列腺癌活性评价，并在 CCl 诱导的人 L-O2 细胞损伤模型中进行保肝活性评价。
首次从该植物中分离得到四个新的黄酮醇-木脂素杂二聚体（1-4）和九个已知的类黄酮衍生物（5-13）。其中一些化合物表现出中等的抗前列腺癌和保肝活性。
化合物 1、2、5 和 6 在 LNCaP 前列腺癌细胞中表现出抗前列腺癌活性，IC 值分别为 17.84、33.26、54.13 和 81.55μg/mL，化合物 3、4、8 和 9 分别表现出中等的保肝活性。本文总结了初步的构效关系。
