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从花朵中分离出的抗炎成分对脂多糖刺激的RAW 264.7巨噬细胞中NF-κB信号通路的抑制作用。

Anti-inflammatory constituents isolated from the flowers of suppression of the NF-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages.

作者信息

He Jie-Wei, Guo Ping, Yang Li, He Jun-Wei

机构信息

Jiangxi University of Chinese Medicine Nanchang 330004 China

Department of Medical Laboratory, First Affiliated Hospital of Nanchang University Nanchang 330006 China.

出版信息

RSC Adv. 2023 Mar 3;13(11):7179-7184. doi: 10.1039/d2ra07623c. eCollection 2023 Mar 1.

DOI:10.1039/d2ra07623c
PMID:36875879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9982826/
Abstract

(Lam.) Aschers flower is traditionally used in China as an important herbal medicine for the treatment of inflammatory disease. The present study isolated one new compound, namely (3)-dihydrobonducellin (1), and five known ones, -hydroxycinnamic acid (2), paprazine (3), thymidine (4), bis(2-ethylhexyl) phthalate (5), and dibutyl phthalate (6) from flowers. These structures were elucidated from spectroscopic data. Among them, compounds 1-4 remarkably suppressed nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells with half maximal inhibitory concentration (IC) values of 19.88 ± 1.81, 39.80 ± 0.85, 19.03 ± 2.35, and 34.63 ± 2.38 μM, respectively. Furthermore, compounds 1 and 3 (20 μM) significantly decreased levels of tumor necrosis factor α (TNF-α), prostaglandin E2 (PGE2), interleukin 1β (IL-1β), and IL-6. Additionally, compounds 1 and 3 (20 μM) prominently reduced the phosphorylation protein level of nuclear factor kappa-B (NF-κB) p65. The present findings indicated that compounds 1 and 3 may be new candidates against inflammation blocking the NF-κB signaling pathway.

摘要

（拉马克）阿舍尔花在中国传统上被用作治疗炎症性疾病的重要草药。本研究从该花中分离出一种新化合物，即（3）-二氢邦杜西林（1），以及五种已知化合物，对羟基肉桂酸（2）、胡椒嗪（3）、胸苷（4）、邻苯二甲酸二（2-乙基己基）酯（5）和邻苯二甲酸二丁酯（6）。这些结构通过光谱数据得以阐明。其中，化合物1 - 4显著抑制脂多糖（LPS）诱导的RAW 264.7细胞中一氧化氮（NO）的产生，其半数最大抑制浓度（IC）值分别为19.88±1.81、39.80±0.85、19.03±2.35和34.63±2.38μM。此外，化合物1和3（20μM）显著降低肿瘤坏死因子α（TNF-α）、前列腺素E2（PGE2）、白细胞介素1β（IL-1β）和IL-6的水平。另外，化合物1和3（20μM）显著降低核因子κB（NF-κB）p65的磷酸化蛋白水平。本研究结果表明，化合物1和3可能是通过阻断NF-κB信号通路来对抗炎症的新候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/121593cfefe9/d2ra07623c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/8e2074370aab/d2ra07623c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/59830bbcd56a/d2ra07623c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/5b01e3c7d68f/d2ra07623c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/315db26ef8b9/d2ra07623c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/121593cfefe9/d2ra07623c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/8e2074370aab/d2ra07623c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/59830bbcd56a/d2ra07623c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/5b01e3c7d68f/d2ra07623c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/315db26ef8b9/d2ra07623c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64db/9982826/121593cfefe9/d2ra07623c-f5.jpg

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本文引用的文献

1
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Biomed Pharmacother. 2022 Sep;153:113295. doi: 10.1016/j.biopha.2022.113295. Epub 2022 Jun 17.
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Anti-inflammatory and antioxidant activities of flavonoids from the flowers of ..花朵中黄酮类化合物的抗炎和抗氧化活性
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(Lam.) Aschers (Yuzan): an overview on its botany, traditional use, phytochemistry, quality control and pharmacology.
（拉姆.）阿舍尔（于赞）：关于其植物学、传统用途、植物化学、质量控制和药理学的概述。
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Anti-inflammatory effects of flavonoids and phenylethanoid glycosides from Hosta plantaginea flowers in LPS-stimulated RAW 264.7 macrophages through inhibition of the NF-κB signaling pathway.玉簪花中类黄酮和苯乙醇苷通过抑制 NF-κB 信号通路对脂多糖刺激的 RAW264.7 巨噬细胞的抗炎作用。
BMC Complement Med Ther. 2022 Mar 3;22(1):55. doi: 10.1186/s12906-022-03540-1.
5
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